Evidence map›Paper›PMID 40164505›Full record

ArticleeNeuro2025

Alpha-Synuclein Phosphomimetic Y39E and S129D Knock-In Mice Show Cytosolic Alpha-Synuclein Localization without Developing Neurodegeneration or Motor Deficits.

YoungDoo Kim, Bhupesh Vaidya, Joseph McInnes, Huda Y Zoghbi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

YoungDoo KimDepartment of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas 77030.
Bhupesh VaidyaDepartment of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas 77030.
Joseph McInnesDepartment of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas 77030.
Huda Y ZoghbiDepartment of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas 77030 hzoghbi@bcm.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor symptoms. Its pathological hallmarks include the accumulation of misfolded alpha-synuclein (α-Syn) in Lewy bodies and Lewy neurites. Phosphorylation of α-Syn is a prominent feature of these inclusions, but its role in disease pathogenesis remains unclear. To identify the role of α-Syn phosphorylation in synucleinopathy, we generated two

Indexed as

alpha-SynucleinBrainCytosolParkinson DiseaseAnimalsDisease Models, AnimalFemaleGene Knock-In TechniquesMaleMiceMice, Inbred C57BLMice, TransgenicMutationPhosphorylationSubstantia Nigraalpha-SynucleinSnca protein, mousealpha-synucleinphosphomimetic mutantsS129DY39E

Identifiers

PMID40164505
PMCPMC11998964

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.