Evidence map›Paper›PMID 40164493›Full record

ArticleBJGP open2025

Saline nasal irrigation for acute sinusitis (SNIFS II): a randomised controlled pilot trial with nested process evaluation.

Roderick P Venekamp, Ben Ainsworth, Tammy Thomas, Beth Stuart, Joanna Slodkowska-Barabasz, Fiona Mowbray, Christopher C Butler, Nick Francis, Samantha Richards-Hall, Anthony Harnden and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJGP open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Roderick P VenekampDepartment of General Practice and Nursing Science, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Ben AinsworthSchool of Psychology, University of Southampton, Southampton, UK.
Tammy ThomasPrimary Care Research Centre, Primary Care & Population Sciences Unit, Aldermoor Health Centre, Faculty of Medicine, University of Southampton, Southampton, UK.
Beth StuartWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0001-5432-7437
Joanna Slodkowska-BarabaszCentre for Clinical and Community Applications of Health Psychology, University of Southampton, Southampton, UK.
Fiona MowbrayNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Christopher C ButlerNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Nick FrancisPrimary Care Research Centre, Primary Care & Population Sciences Unit, Aldermoor Health Centre, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0001-8939-7312
Samantha Richards-HallPrimary Care Research Centre, Primary Care Population Sciences and Medical Education Unit, University of Southampton, Southampton, UK.
Anthony HarndenNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Alastair D HayUniversity of Bristol, Centre for Academic Primary Care, Bristol Medical School, Population Health Sciences, Bristol, UK.
Claire HopkinsDepartment of Rhinology and Skull Base Surgery, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
Michael MoorePrimary Care Research Centre, Primary Care & Population Sciences Unit, Aldermoor Health Centre, Faculty of Medicine, University of Southampton, Southampton, UK.
Lucy YardleyCentre for Clinical and Community Applications of Health Psychology, University of Southampton, Southampton, UK.
Theo Jm VerheijDepartment of General Practice and Nursing Science, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-0166-1498
Shihua ZhuHealth Economics Department, Primary Care & Population Sciences Unit, Aldermoor Health Centre, Faculty of Medicine, University of Southampton, Southampton, UK.
Paul LittlePrimary Care Research Centre, Primary Care & Population Sciences Unit, Aldermoor Health Centre, Faculty of Medicine, University of Southampton, Southampton, UK p.little@soton.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite having marginal beneficial effects, antibiotics are routinely prescribed in adults with acute sinusitis. Alternative interventions for this common condition are urgently needed.

aimTo assess the feasibility and acceptability of saline nasal irrigation for acute sinusitis. DESIGN &

settingRandomised controlled pilot trial with nested process evaluation in 24 English general practices between October 2019 and May 2021.

methodParticipants were randomised to advice to high-volume hypertonic saline nasal irrigation with a delayed antibiotic prescription or usual care. Feasibility outcomes included recruitment and follow-up rates, adherence, and acceptability of the intervention.

resultsOf those invited,

conclusionSaline nasal irrigation is deemed acceptable for adults with acute sinusitis and a trial of such intervention is feasible. A large trial is warranted to assess the effectiveness of this intervention for this common condition.

Indexed as

acute sinusitisnasal lavageprimary health caresaline nasal irrigationsinusitis

Identifiers

PMID40164493
PMCPMC12728885

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.