ArticleOrganic letters2025
One-Pot Total Synthesis of a Post-translationally Modified Max Transcription Factor Sheds Light on Ser-Phosphorylation and Lys-Acetylation Crosstalk in DNA Binding.
Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Advancing protein engineering via organic chemistry.Communications chemistry · 2026Review
- Total Chemical Synthesis of RNF4 by Sequential Native Chemical Ligation: C-To-N Versus N-To-C Strategies.The Journal of organic chemistry · 2026Article
- Engineering Light-Responsive Transcription Factors via Strategic Masking of Post-translational Modification Residues.Bioconjugate chemistry · 2026Article
- Chemical Engineering of Transcription Factors Uncovered Cell-Permeable μMax Modulators.Journal of the American Chemical Society · 2025Article
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3 authors.
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Abstract
We report a one-pot total synthesis of the transcription factor Max in seven consecutive steps, starting from three peptide segments and employing native chemical ligation. The developed synthesis facilitates the generation of homogeneous Max analogues bearing defined transformations within hours in excellent yields, enabling us to probe the effect of the crosstalk between Ser-phosphorylation and Lys-acetylation on the Max function. Our findings reveal that these post-translational modifications significantly inhibit DNA-binding activity, potentially by disrupting essential Max-DNA interactions.
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