Evidence map›Paper›PMID 40163721›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Cryo-EM structure of cyanopodophage A4 reveals a pentameric pre-ejectosome in the double-stabilized capsid.

Pu Hou, Rui-Qian Zhou, Yong-Liang Jiang, Rong-Cheng Yu, Kang Du, Nanqin Gan, Fei Ke, Qi-Ya Zhang, Qiong Li, Cong-Zhao Zhou

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pu Hou *Department of Radiology, The First Affiliated Hospital of University of Science and Technology of China and School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Rui-Qian Zhou *Department of Radiology, The First Affiliated Hospital of University of Science and Technology of China and School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.ORCID 0009-0005-6089-8654
Yong-Liang JiangDepartment of Radiology, The First Affiliated Hospital of University of Science and Technology of China and School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Rong-Cheng YuDepartment of Radiology, The First Affiliated Hospital of University of Science and Technology of China and School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Kang DuDepartment of Radiology, The First Affiliated Hospital of University of Science and Technology of China and School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Nanqin GanInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Fei KeInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Qi-Ya ZhangInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Qiong LiDepartment of Radiology, The First Affiliated Hospital of University of Science and Technology of China and School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0003-2838-9380
Cong-Zhao ZhouDepartment of Radiology, The First Affiliated Hospital of University of Science and Technology of China and School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0002-6881-7151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upon infection, the podophages usually eject a couple of proteins from the capsid to form a transmembrane ejectosome on the host cell membrane that facilitates the ejection of viral genome. However, it remains unclear how these proteins of pre-ejectosome are finely assembled at the center of highly packaged genome. Here, we report the intact structure of

Indexed as

BacteriophagesCapsidPodoviridaeCapsid ProteinsCryoelectron MicroscopyCyanobacteriaDNA, ViralGenome, ViralVirus AssemblyCapsid ProteinsDNA, ViralAnabaenacryo-EM structureejectosomepodophageviral genome packaging

Identifiers

PMID40163721
PMCPMC12002296

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.