Evidence map›Paper›PMID 40163677›Full record

ArticleJournal of medicinal chemistry2025

Discovery and Early Optimization of 1

Ramon G de Oliveira, Luiza R Cruz, Marco A Dessoy, Paul J Koovits, Deborah A Dos Santos, Luiz F N de Oliveira, Rafael A Ferreira, María C Mollo, Eun Lee, Simone M Duarte and 17 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Ramon G de OliveiraInstitute of Chemistry, State University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0002-2407-5766
Luiza R CruzInstitute of Chemistry, State University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0001-6103-9345
Marco A DessoyInstitute of Chemistry, State University of Campinas, Campinas 13083-862, Brazil.ORCID 0009-0005-5731-761X
Paul J KoovitsInstitute of Chemistry, State University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0002-8435-9437
Deborah A Dos SantosInstitute of Chemistry, State University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0001-5677-1857
Luiz F N de OliveiraInstitute of Chemistry, State University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0002-6530-3120
Rafael A FerreiraInstitute of Chemistry, State University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0001-9866-2667
María C MolloInstitute of Chemistry, State University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0001-8040-2533
Eun LeeInstitute of Chemistry, State University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0001-6893-4799
Simone M DuarteSão Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.ORCID 0000-0003-3132-1037
Renata KroghSão Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.ORCID 0000-0002-6545-608X
Leonardo L G FerreiraSão Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.ORCID 0000-0002-6947-0639
Rafael C ChelucciSão Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.ORCID 0009-0008-4099-9986
Quillon J SimpsonORCID 0000-0002-1074-9838
Adriana C da SilvaORCID 0000-0002-1273-3450
Benedito M Dos SantosORCID 0000-0002-2196-260X
Milena F BroeringORCID 0000-0001-6748-882X
Michael P PollastriORCID 0000-0001-9943-7197
Carolina B MoraesORCID 0000-0002-0689-2770
Adriano D AndricopuloSão Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.ORCID 0000-0002-0457-818X
Jadel M KratzDrugs for Neglected Diseases initiative, Rio de Janeiro 20010-020, Brazil.ORCID 0000-0002-7681-8234
Peter SjöDrugs for Neglected Diseases initiative, Geneva 1202, Switzerland.ORCID 0000-0002-6768-0536
Charles E MowbrayDrugs for Neglected Diseases initiative, Geneva 1202, Switzerland.ORCID 0000-0003-3538-8116
Luiz C DiasInstitute of Chemistry, State University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0003-0628-9928

Funding

Lead optimization of hits identified from virtual and experimental screens of multiple industrial libraries DNDiR33AI141227 · NIAID · NORTHEASTERN UNIVERSITY · PI FERRINS, LORI · 2021 to 2023
$1.2M
NIAID NIH HHS R33 AI141227
6 · The paper itself

Abstract

Chagas disease (CD), caused by the flagellate protozoan

Indexed as

IndolesTrypanocidal AgentsTrypanosoma cruziAnimalsChagas DiseaseDrug DiscoveryHumansMiceParasitic Sensitivity TestsStructure-Activity RelationshipIndolesTrypanocidal Agents

Identifiers

PMID40163677
PMCPMC11998015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.