Evidence map›Paper›PMID 40163651›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2025

State of the Art of Artificial Intelligence in Clinical Electrophysiology in 2025: A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), and the ESC Working Group on E-Cardiology.

Emma Svennberg, Janet K Han, Enrico G Caiani, Sandy Engelhardt, Sabine Ernst, Paul Friedman, Rodrigue Garcia, Hamid Ghanbari, Gerhard Hindricks, Sharon H Man and 18 more

Registry-linked trialAbstract read
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02997254 (COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02997254 recruitingnot on this map

COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation

TypeobservationalSponsorStanford UniversityRan2016 to 2027Enrolled1,000ConditionsAtrial Fibrillation, Abnormal Heart Rhythms
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Intracardiac Echocardiography during Invasive Electrophysiological Procedures: a Scientific Statement of the European Heart Rhythm Association of the ESC, and the European Association of Percutaneous Cardiovascular Interventions of the ESC.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Guideline
  2. Sedation and anaesthesia in pulsed-field ablation for atrial fibrillation: mechanisms, procedural requirements, and real-world practice.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Review
  3. LifeRhythms: The continuous commitment of the European Heart Rhythm Association in the field of arrhythmias and electrophysiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  4. Review
  5. The second beat matters: coupling intervals and sudden cardiac death risk in hypertrophic cardiomyopathy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  6. Combined unipolar and bipolar voltage mapping for atrial substrate assessment: associations with arrhythmia recurrence after redo ablation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  7. [AI-Assisted ECG diagnostics : Classical test statistics still apply].Herzschrittmachertherapie & Elektrophysiologie · 2026
    Review
  8. Review
  9. Artificial intelligence-enhanced electrocardiography for prediction of cancer therapy-related cardiac dysfunction.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Digitally assisted learning in cardiac electrophysiology and cardiac implantable electronic devices: a Scientific Statement of the European Heart Rhythm Association of the ESC.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Review
  16. Sex-specific virtual population for the prediction and assessment of arrhythmia risk.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  17. Screening for atrial fibrillation using an ECG monitoring patch among the elderly population in rural China: a single-arm study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  18. Article
  19. Review
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Emma SvennbergDepartment of Medicine (Med H), Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-6413-0870
Janet K HanDivision of Cardiology and Cardiology Arrhythmia Service, VA Greater Los Angeles Healthcare Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0003-2393-7018
Enrico G CaianiPolitecnico di Milano, Electronics, Information and Bioengineering Department, Milan, Italy.ORCID 0000-0002-1770-6486
Sandy EngelhardtDepartment of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0001-8816-7654
Sabine ErnstDivision of Cardiology, Royal Brompton Hospital, Guys and St Thomas' Foundation Trust, London, United Kingdom.ORCID 0000-0003-1258-2477
Paul FriedmanDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-5052-2948
Rodrigue GarciaCardiology Department, University Hospital of Poitiers, Poitiers, France.ORCID 0000-0001-9350-2437
Hamid GhanbariDepartment of Internal Medicine, Division of Cardiology, Section of Electrophysiology, University of Michigan, Ann Arbor, USA.
Gerhard HindricksGerman Heart Center Charite, Berlin, Germany.ORCID 0000-0002-0132-0773
Sharon H ManDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.ORCID 0000-0002-1787-1860
José MilletEP Analytics Lab, Instituto ITACA, Universitat Politècnica de Valencia & Center for Biomedical Network Research on Cardiovascular Diseases (CIBERCV), Valencia, Spain.ORCID 0000-0002-8879-003X
Sanjiv M NarayanDepartment of Medicine, Cardiovascular Division, Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7552-5053
G André NgLeicester British Heart Foundation Centre of Research Excellence, National Institute for Health and Care Research Leicester Biomedical Research Centre, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.ORCID 0000-0001-5965-0671
Peter A NoseworthyDivision of Heart Rhythm Services, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-4308-0456
Fleur V Y TjongDepartment of Cardiology, Heart Center, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.ORCID 0000-0001-9608-0081
Julia RamírezCentro de Investigación Biomédica en Red, Biomateriales, Bioingeniería y Nanomedicina, Zaragoza, Spain.ORCID 0000-0003-4130-5866
Jagmeet P SinghMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2724-529X
Natalia TrayanovaDepartment of Biomedical Engineering and Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-8661-063X
David DunckerHannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-2996-6338
Jacob Tfelt HansenSection of genetics, Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Joseph BarkerNational Heart and Lung Institute, Imperial College London, London, UK.
Ruben Casado-ArroyoDepartment of Cardiology, H.U.B.-Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Neal A ChatterjeeAssociate Professor of Medicine Division of Cardiology, University of Washington Seattle, Seattle, WA, USA.
Giulio ConteDepartment of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Søren Zöga DiederichsenDepartment of Cardiology, University Hospital Copenhagen-Rigshospitalet Copenhagen, Copenhagen, Denmark.
Dominik LinzDepartment of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands.
Arun Umesh MahtaniCardiology Fellow Department of Cardiology, Virginia Commonwealth University, Richmond, VA, USA.
Alessandro ZorziDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Funding

The Dynamics of Human Atrial FibrillationR01HL083359 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sanjiv M Narayan · 2008 to 2026
$7.9M
Machine Learning in Atrial FibrillationR01HL149134 · NHLBI · STANFORD UNIVERSITY · PI NARAYAN, SANJIV M · 2020 to 2024
$3.8M
Artificial intelligence analysis of atrial remodeling evolution in patients with atrial fibrillation: Towards optimal ablation strategiesR01HL166759 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Eugene Kholmovski, David Spragg · 2023 to 2026
$3.2M
Machine Learning for Ventricular ArrhythmiasR01HL162260 · NHLBI · STANFORD UNIVERSITY · PI Sanjiv M Narayan · 2023 to 2026
$2.5M
Heart Digital Twin Analysis of Arrhythmias due to Infiltrating AdiposityR01HL174440 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NATALIA A. TRAYANOVA · 2024 to 2026
$2.1M
AEIBritish Heart Foundation RE/24/13003Dutch Research CouncilEuropean Union CNS2023-143599European Union PID2021-128972OA-I00European Union PID2023-148975OB-I00Healthcare Innovation Fund HI/C2/24/360038MCINNational Institute for Health and Care Research NIHR204553NHLBI NIH HHS R01 HL083359NHLBI NIH HHS R01 HL149134NHLBI NIH HHS R01 HL162260NHLBI NIH HHS R01 HL166759NHLBI NIH HHS R01 HL174440NIH HHS R01HL166759NIH HHS R01HL174440Stockholm County CouncilSwedish Heart and Lung AssociationSwedish Research Council DNR 2022-01466
6 · The paper itself

Abstract

aimsArtificial intelligence (AI) has the potential to transform cardiac electrophysiology (EP), particularly in arrhythmia detection, procedural optimization, and patient outcome prediction. However, a standardized approach to reporting and understanding AI-related research in EP is lacking. This scientific statement aims to develop and apply a checklist for AI-related research reporting in EP to enhance transparency, reproducibility, and understandability in the field. METHODS AND

resultsAn AI checklist specific to EP was developed with expert input from the writing group and voted on using a modified Delphi process, leading to the development of a 29-item checklist. The checklist was subsequently applied to assess reporting practices to identify areas where improvements could be made and provide an overview of the state of the art in AI-related EP research in three domains from May 2021 until May 2024: atrial fibrillation (AF) management, sudden cardiac death (SCD), and EP lab applications. The EHRA AI checklist was applied to 31 studies in AF management, 18 studies in SCD, and 6 studies in EP lab applications. Results differed between the different domains, but in no domain reporting of a specific item exceeded 55% of included papers. Key areas such as trial registration, participant details, data handling, and training performance were underreported (<20%). The checklist application highlighted areas where reporting practices could be improved to promote clearer, more comprehensive AI research in EP.

conclusionThe EHRA AI checklist provides a structured framework for reporting AI research in EP. Its use can improve understanding but also enhance the reproducibility and transparency of AI studies, fostering more robust and reliable integration of AI into clinical EP practice.

Indexed as

Arrhythmias, CardiacArtificial IntelligenceAtrial FibrillationCardiac ElectrophysiologyElectrophysiologic Techniques, CardiacChecklistConsensusDeath, Sudden, CardiacDelphi TechniqueHumansArtificial intelligenceChecklistElectrophysiologyMachine learning

Identifiers

PMID40163651
PMCPMC12123071

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.