Evidence map›Paper›PMID 40163417›Full record

ArticleAging2025

Accelerated aging associated with cancer characteristics and treatments among breast cancer survivors.

Cong Wang, Jill B De Vis, Kirsten Nguyen, Brigitte Jia, Mason Alford, Marjan Rafat, Bapsi Chakravarthy, Xiao-Ou Shu

Abstract read
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cong WangDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37235, USA.
Jill B De VisDepartment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37235, USA.
Kirsten NguyenVanderbilt University School of Medicine, Nashville, TN 37235, USA.
Brigitte JiaVanderbilt University School of Medicine, Nashville, TN 37235, USA.
Mason AlfordVanderbilt University School of Medicine, Nashville, TN 37235, USA.
Marjan RafatDepartment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37235, USA.
Bapsi ChakravarthyDepartment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37235, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37235, USA.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
TISSUE CoreP50CA098131 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARK, BEN HO, PIETENPOL, JENNIFER A · 2003 to 2024
$48.7M
NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA098131
6 · The paper itself

Abstract

Breast cancer (BC) survivors may experience accelerated aging due to detrimental effects of BC and/or its treatments. Our study aims to evaluate Phenotypic Age Acceleration (PAA), a biological age measure, among BC patients and assess its associations with cancer characteristics and treatments. In this study including 1264 BC patients (age 54.7±11.7) and 429 cancer-free controls (age 49.9±12.4), we evaluated the differences in PAA (ΔPAA) by BC characteristics and treatments at multiple time points using linear mixed models. Overall, BC survivors had a higher PAA than controls at diagnosis (ΔPAA=3.73,

Indexed as

Aging, PrematureBreast NeoplasmsCancer SurvivorsAdultAgedFemaleHumansMiddle Agedaccelerated agingbreast cancerPhenoAgesurvivors

Identifiers

PMID40163417
PMCPMC11984420

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.