Evidence map›Paper›PMID 40163413›Full record

ArticleJournal of medicinal chemistry2025

Real Way to Target Gram-Negative Pathogens: Discovery of a Novel

Jonah Pascal Propp, Damien Oz Castor, M Ashley Spies

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jonah Pascal ProppDepartment of Pharmaceutical Sciences and Experimental Therapeutics, The University of Iowa College of Pharmacy, Iowa City, Iowa 52242, United States.
Damien Oz CastorDepartment of Biochemistry, Carver College of Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242-1109, United States.
M Ashley SpiesDepartment of Pharmaceutical Sciences and Experimental Therapeutics, The University of Iowa College of Pharmacy, Iowa City, Iowa 52242, United States.ORCID 0000-0002-1248-5362

Funding

Dialing down caspase-7 through allosteric control: An integrated approachR01GM138471 · NIGMS · UNIVERSITY OF IOWA · PI SPIES, MICHAEL ASHLEY · 2020 to 2023
$1.2M
NIGMS NIH HHS R01 GM138471
6 · The paper itself

Abstract

In an era of escalating antibiotic resistance, there is a pressing need for innovative strategies to develop novel antibiotics. Gram-negative bacteria, characterized by their robust dual-membrane, are intrinsically resistant to a wide range of antibiotics and can readily develop new resistances. Members of this bacterial class comprise numerous pathogenic organisms, including the primary cause of gastric cancer,

Indexed as

Amino Acid IsomerasesAnti-Bacterial AgentsDrug DiscoveryHelicobacter pyloriDrug Resistance, BacterialHumansMicrobial Sensitivity TestsStructure-Activity RelationshipAmino Acid IsomerasesAnti-Bacterial Agentsglutamate racemase

Identifiers

PMID40163413
PMCPMC12105023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.