Evidence map›Paper›PMID 40163381›Full record

ReviewExpert review of respiratory medicine2025

An overview of patient-ventilator asynchrony in children.

Benjamin Yoon, Robert Blokpoel, Chatila Ibn Hadj Hassine, Yukie Ito, Kevin Albert, Melissa Aczon, Martin C J Kneyber, Guillaume Emeriaud, Robinder G Khemani

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert review of respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin YoonSection of Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Robert BlokpoelDepartment of Paediatrics, Division of Paediatric Intensive Care, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Chatila Ibn Hadj HassinePediatric Intensive Care Unit, CHU Sainte Justine, Universite ́ de Montre ́al, Montreal, Quebec C, Canada.
Yukie ItoDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Kevin AlbertPediatric Intensive Care Unit, CHU Sainte Justine, Universite ́ de Montre ́al, Montreal, Quebec C, Canada.
Melissa AczonLaura P. and Leland K. Whittier Virtual Pediatric Intensive Care Unit, Department of Anesthesiology Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Martin C J KneyberDepartment of Paediatrics, Division of Paediatric Intensive Care, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Guillaume EmeriaudPediatric Intensive Care Unit, CHU Sainte Justine, Universite ́ de Montre ́al, Montreal, Quebec C, Canada.
Robinder G KhemaniDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Los Angeles, Los Angeles, CA, USA.

Funding

Patient Ventilator Asynchrony in Critically Ill ChildrenR01HL164397 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Robinder Khemani · 2023 to 2026
$2.8M
NHLBI NIH HHS R01 HL164397
6 · The paper itself

Abstract

introductionMechanically ventilated children often have patient-ventilator asynchrony (PVA). When a ventilated patient has spontaneous effort, the ventilator attempts to synchronize with the patient, but PVA represents a mismatch between patient respiratory effort and ventilator delivered breaths. AREAS COVERED: This review will focus on subtypes of patient ventilator asynchrony, methods to detect or measure PVA, risk factors for and characteristics of patients with PVA subtypes, potential clinical implications, treatment or prevention strategies, and future areas for research. Throughout this review, we will provide pediatric specific considerations. EXPERT OPINION: PVA in pediatric patients supported by mechanical ventilation occurs frequently and is understudied. Pediatric patients have unique physiologic and pathophysiologic characteristics which affect PVA. While recognition of PVA and its subtypes is important for bedside clinicians, the clinical implications and risks versus benefits of treatment targeted at reducing PVA remain unknown. Future research should focus on harmonizing PVA terminology, refinement of automated detection technologies, determining which forms of PVA are harmful, and development of PVA-specific ventilator interventions.

Indexed as

LungRespiration, ArtificialRespiratory InsufficiencyRespiratory MechanicsAge FactorsChildHumansPatient-Ventilator AsynchronyRisk FactorsVentilators, Mechanicalmechanical ventilationPatient ventilator asynchronypatient ventilator dyssynchronypediatricventilator management

Identifiers

PMID40163381
PMCPMC12109136

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.