Evidence map›Paper›PMID 40163373›Full record

ArticleEnvironmental health perspectives2025

Endocrine-Disrupting Chemicals and Persistent Nausea among Pregnant Women Enrolled in the Illinois Kids Development Study (I-KIDS).

Brad A Ryva, Blair J Wylie, Max T Aung, Susan L Schantz, Rita S Strakovsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Associations of endocrine disrupting chemicals with anogenital distance across infancy.The Journal of clinical endocrinology and metabolism · 2026
    Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brad A RyvaDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA.
Blair J WylieDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Max T AungDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Susan L SchantzThe Beckman Institute, University of Illinois, Urbana-Champaign, Illinois, USA.
Rita S StrakovskyInstitute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-3551-1615

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUH3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Andrea Aguiar, Susan L Schantz · 2018 to 2026
$18.6M
MULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGYT32ES007255 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHN J LAPRES · 1989 to 2026
$9.3M
Project 3: Endocrine Disruptors and Diet: Effects on the Developing Cortex P01ES022848 · NIEHS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SCHANTZ, SUSAN L · 2013 to 2018
$4.2M
Exposure to phthalate mixtures in pregnancy and long-term consequences for maternal metabolic and hormonal statusR01ES032227 · NIEHS · MICHIGAN STATE UNIVERSITY · PI STRAKOVSKY, RITA S. · 2020 to 2025
$2.1M
RISK MANAGEMENT IN NATIVE AMERICAN COMMUNITIESR25ES007255 · NIEHS · CLARK UNIVERSITY (WORCESTER, MA) · PI GOBLE, ROBERT L · 1994 to 2002
$738k
Endocrine Disruptors: Maternal Estrogen, Metabolism and Fetal Fatty Acid SupplyR00ES024795 · NIEHS · MICHIGAN STATE UNIVERSITY · PI STRAKOVSKY, RITA S. · 2017 to 2019
$729k
Endocrine Disruptors: Maternal Estrogen, Metabolism and Fetal Fatty Acid SupplyK99ES024795 · NIEHS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI STRAKOVSKY, RITA S. · 2015 to 2016
$198k
NIDDK NIH HHS P30 DK020572NIEHS NIH HHS K99 ES024795NIEHS NIH HHS P01 ES022848NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R00 ES024795NIEHS NIH HHS R01 ES032227NIEHS NIH HHS R25 ES007255NIEHS NIH HHS T32 ES007255NIH HHS UH3 OD023272
6 · The paper itself

Abstract

backgroundPregnant women are exposed to numerous endocrine-disrupting chemicals (EDCs). Pregnancy-related nausea likely has hormonal etiology and may persist beyond the first trimester.

objectivesTherefore, we aimed to determine the relationship between EDC biomarkers and pregnancy nausea characteristics.

methodsIllinois Kids Development Study (I-KIDS) pregnant women (

resultsOnly the sum of urinary biomarkers of di(isononyl) cyclohexane-1,2-dicarboxylate ( DISCUSSION: Nonpersistent EDCs, modeled as a mixture, are associated with persistent nausea in pregnancy, primarily in women carrying males. Future work should explore possible mechanisms, clinical implications, and interventions to reduce exposures and symptoms. https://doi.org/10.1289/EHP15547.

Indexed as

Endocrine DisruptorsEnvironmental PollutantsMaternal ExposureNauseaAdultBiomarkersFemaleHumansIllinoisPhthalic AcidsPregnancyBiomarkersEndocrine DisruptorsEnvironmental PollutantsPhthalic Acids

Identifiers

PMID40163373
PMCPMC12077660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.