Evidence map›Paper›PMID 40163279›Full record

ArticleAnnals of intensive care2025

Time-dependent effects of prone position on ventilation-perfusion matching assessed by electrical impedance tomography in patients with COVID-19 ARDS: sub-analysis of a prospective physiological study.

Yuxian Wang, Yaxiaerjiang Muhetaer, Xin Zheng, Wei Wu, Jiale Tao, Ling Zhu, Jieqiong Song, Zhanqi Zhao, Ming Zhong

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04725227 (Determine the Effect of Prone Positioning on Lung Ventilation and Perfusion Distribution in Adults With Acute Respiratory Distress Syndrome by Electrical Impedance Tomography), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04725227 unknown statusnot on this map

Determine the Effect of Prone Positioning on Lung Ventilation and Perfusion Distribution in Adults With Acute Respiratory Distress Syndrome by Electrical Impedance Tomography

TypeobservationalSponsorShanghai Zhongshan HospitalRan2020 to 2022Enrolled20ConditionsARDS, Prone Position, Electrical Impedance Tomography
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuxian Wang *Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yaxiaerjiang Muhetaer *Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xin Zheng *Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wei WuDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jiale TaoDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Ling ZhuDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jieqiong SongDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. song.jieqiong@zs-hospital.sh.cn.
Zhanqi ZhaoSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China. zhanqizhao@gzhmu.edu.cn.
Ming ZhongDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. zhong.ming@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0002-5578-5277

Funding

National Natural Science Foundation of China Grant NO.81971807Science and Technology Innovation Plan Of Shanghai Science and Technology Commission 202240334
6 · The paper itself

Abstract

backgroundProne positioning (PP) has been shown to improve oxygenation in patients with acute respiratory distress syndrome (ARDS); with a focus on its early physiological effects. However, the time-dependent effects of PP on ventilation-perfusion (V/Q) matching have not been fully investigated. In this study we aimed to investigate the longitudinal effects of PP on regional V/Q matching and the distribution of ventilation and perfusion in patients with coronavirus disease 2019 (COVID-19)-associated ARDS.

methodsThis study analyzed patients with COVID-19 ARDS who were mechanically ventilated and underwent their first PP treatment. V/Q mismatching was assessed using electrical impedance tomography (EIT). At five intervals during the initial PP session PaO

resultsIn this study eighteen COVID-19 ARDS patients were enrolled. In comparison with SP, PP led to significant improvements in oxygenation, with PaO

conclusionsIn COVID-19-induced ARDS patients, prone positioning initially improves oxygenation and V/Q matching by enhancing ventilation distribution and decreasing low V/Q (%). Over time, perfusion changes further improve V/Q matching, but these benefits diminish once the patient returns to the supine position, leading to increased V/Q mismatch. Trial registration Clinical Trials.gov, NCT04725227. Registered 25 January 2021, https://clinicaltrials.gov/study/NCT04725227?cond=NCT04725227&rank=1.

Indexed as

Acute respiratory distress syndromeElectrical impedance tomographyMechanical ventilationProne positioningPulmonary perfusionVentilation-perfusion matching

Identifiers

PMID40163279
PMCPMC11958859

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.