ArticleJournal of fluorescence2025
TBP-based AIE Fluorescent Probe for Cysteine/Homocysteine Detection and Imaging in Living Cells.
Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The abnormality expression of biothiols in organisms may give rise to a number of pathological conditions. Therefore, the accurate detection of biothiols is of significant importance for the diagnosis of diseases associated with their aberrant levels. In this paper, we designed a small molecule fluorescent probe with good AIE performance to specifically detect Cys/Hcy, which makes up for the limitation of probes with aggregation-induced quenching effect. The probe was synthesized by coupling 7-nitro-1,2,3-benzenediazole (NBD) as a recognition group to the fluorophore TBP, which has obvious aggregation-induced emission effect (AIE). The Cys/Hcy thiol functional group cut off the ether bond of TBP-NBD, NBD-Cys/Hcy with strong fluorescence was generated, results in a 50 ~ 100 folds increase in fluorescence intensity indicating the fluorescence was turned on. However, the fluorescence intensity was not significantly enhanced after co-incubation with GSH, which could achieve a good distinction between Cys/Hcy and GSH. In this paper, a series of experiments show that TBP-NBD has good Cys/Hcy identification ability.
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