Evidence map›Paper›PMID 40163028›Full record

ArticleeLife2025

2-oxoglutarate triggers assembly of active dodecameric

Eva Herdering, Tristan Reif-Trauttmansdorff, Anuj Kumar, Tim Habenicht, Georg Hochberg, Stefan Bohn, Jan Schuller, Ruth Anne Schmitz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Glutamine metabolic enzymes: to filament or not to filament?Biochemical Society transactions · 2026
    Review
  2. Construction of RecombinantMicroorganisms · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eva Herdering *Institute for General Microbiology, Christian Albrechts University, Kiel, Germany.
Tristan Reif-Trauttmansdorff *Center for Synthetic Microbiology (SYNMIKRO) Research Center and Department of Chemistry, Philipps-Universität Marburg, Marburg, Germany.
Anuj KumarCenter for Synthetic Microbiology (SYNMIKRO) Research Center and Department of Chemistry, Philipps-Universität Marburg, Marburg, Germany.
Tim HabenichtInstitute for General Microbiology, Christian Albrechts University, Kiel, Germany.
Georg HochbergCenter for Synthetic Microbiology (SYNMIKRO) Research Center and Department of Chemistry, Philipps-Universität Marburg, Marburg, Germany.
Stefan BohnCryo-Electron Microscopy Platform and Institute of Structural Biology, Helmholtz Munich, Neuherberg, Germany.
Jan SchullerCenter for Synthetic Microbiology (SYNMIKRO) Research Center and Department of Chemistry, Philipps-Universität Marburg, Marburg, Germany.
Ruth Anne SchmitzInstitute for General Microbiology, Christian Albrechts University, Kiel, Germany.ORCID https://orcid.org/0000-0002-6788-0829

Funding

Deutsche Forschungsgemeinschaft Schm1052/20-2Deutsche Forschungsgemeinschaft SCHU 3364/1-1European Research Council 10.3030/101075992
6 · The paper itself

Abstract

Glutamine synthetases (GS) are central enzymes essential for the nitrogen metabolism across all domains of life. Consequently, they have been extensively studied for more than half a century. Based on the ATP-dependent ammonium assimilation generating glutamine, GS expression and activity are strictly regulated in all organisms. In the methanogenic archaeon

Indexed as

Archaeal ProteinsGlutamate-Ammonia LigaseKetoglutaric AcidsMethanosarcinaCryoelectron MicroscopyProtein MultimerizationArchaeal ProteinsGlutamate-Ammonia LigaseKetoglutaric Acids2-oxoglutaratearchaeabiochemistrychemical biologyglutamine synthetaseinfectious diseaseMethanosarcina mazeimicrobiologynitrogen metabolismregulation

Identifiers

PMID40163028
PMCPMC11957540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.