Evidence map›Paper›PMID 40162832›Full record

ArticleMicrobiology spectrum2025

Synergistic antifungal activity of minocycline as an effective augmenting agent of fluconazole against drug-resistant

Yun-Zhu Zhu, Xiang Li, Qing-Yue Zhang, Ning Yang, Ping Tian, Ding Zhang, Yi Yang, Liang Yu, Yan-Yan Liu, Ying Ye and 2 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yun-Zhu Zhu *Department of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Xiang Li *Department of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Qing-Yue ZhangDepartment of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Ning YangDepartment of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Ping TianDepartment of Gastroenterology, Linyi People's Hospital, Linyi, Shandong, China.
Ding ZhangDepartment of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yi YangDepartment of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Liang YuDepartment of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yan-Yan LiuDepartment of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Ying YeDepartment of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Ya-Sheng LiDepartment of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID 0009-0002-5703-6445
Jia-Bin LiDepartment of Infectious Diseases & Anhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID 0000-0002-6539-1802

Funding

National Natural Science Foundation of China 82270015 82302577 82304209 81973983
6 · The paper itself

Abstract

Invasive candidiasis has emerged as a significant healthcare challenge, with a rising incidence rate attributed to the widespread use of organ transplantation, chemotherapy, immunosuppressants, and broad-spectrum antibiotics. The increasing prevalence of drug-resistant strains, particularly among IMPORTANCE: This study highlights the potential of minocycline and fluconazole combination therapy in combating drug-resistant

Indexed as

Antifungal AgentsCandida tropicalisDrug Resistance, FungalFluconazoleMinocyclineAnimalsCandidiasisDisease Models, AnimalDrug SynergismDrug Therapy, CombinationLarvaMiceMicrobial Sensitivity TestsMothsAntifungal AgentsFluconazoleMinocyclineantifungal therapyCandida tropicalisfluconazole resistanceminocyclineRNA sequencingsynergistic effect

Identifiers

PMID40162832
PMCPMC12054018

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.