Evidence map›Paper›PMID 40162794›Full record

ArticlemSphere2025

Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against

Carlos Espinosa-Vinals, Jana Holubova, Ondrej Stanek, Radim Osicka, Jiri Masin, Fresia Esther Arellano Herencia, Peter Sebo

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carlos Espinosa-VinalsLaboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.ORCID 0000-0002-9622-2331
Jana HolubovaLaboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.ORCID 0000-0002-0829-0976
Ondrej StanekLaboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.ORCID 0000-0003-1575-7834
Radim OsickaLaboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.ORCID 0000-0003-2626-5456
Jiri MasinLaboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.ORCID 0000-0001-6258-4599
Fresia Esther Arellano HerenciaLaboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
Peter SeboLaboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.ORCID 0000-0002-9755-7715

Funding

Czech Science Foundation GX19-27630XMinistry of Education, Youth and Sports of the Czech Republic LX22NPO5103, CZ.02.01.01/00/22_008/0004597,LM2023053, CZ.02.1.01./0.0/0.0/18_046/0015974, LM2023042,LM2018127,CZ.02.01.01/00/22_008/0004597
6 · The paper itself

Abstract

The adenylate cyclase toxin (ACT, AC-Hly, or CyaA) plays a key role in airway infections by IMPORTANCE: Despite high vaccine coverage, unexpectedly massive whooping cough outbreaks are currently resurging in the most developed countries using the acellular pertussis (aP) vaccine. Accelerated development of improved aP vaccines, conferring a more complete and longer-lasting protection of the airway from

Indexed as

Adenylate Cyclase ToxinAntigens, BacterialBacterial Outer Membrane ProteinsBordetella pertussisPertussis VaccineRespiratory MucosaVirulence Factors, BordetellaWhooping CoughAdministration, IntranasalAnimalsAntibodies, BacterialAntibodies, NeutralizingFemaleHumansMiceMice, Inbred BALB CAdenylate Cyclase ToxinAntibodies, BacterialAntibodies, NeutralizingAntigens, BacterialBacterial Outer Membrane ProteinspertactinPertussis VaccineRecombinant Fusion ProteinsVirulence Factors, Bordetellaadenylate cyclase toxinBordetella pertussispertactinpertussisprotectionprotein foldingwhooping cough

Identifiers

PMID40162794
PMCPMC12039270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.