Evidence map›Paper›PMID 40162785›Full record

ArticleJournal of virology2025

Toll-like receptor 7 (TLR7)-mediated antiviral response protects mice from lethal SARS-CoV-2 infection.

Roshan Ghimire, Rakshya Shrestha, Radhika Amaradhi, Lin Liu, Sunil More, Thota Ganesh, Alexandra K Ford, Rudragouda Channappanavar

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. COVID-19, the disease that changed the world.Medicine and pharmacy reports · 2026
    Review
  3. Review
  4. Article
  5. Unraveled role of TLR7-mediated interferon signaling activation in COVID-19.Frontiers in cellular and infection microbiology · 2025
    Review
  6. Review
  7. Modulation ofFrontiers in immunology · 2025
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Roshan Ghimire *Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.ORCID 0000-0002-1397-3966
Rakshya Shrestha *Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.ORCID 0000-0002-1109-7966
Radhika AmaradhiDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
Lin LiuDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.ORCID 0000-0002-4811-4897
Sunil MoreDepartment of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.
Thota GaneshDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-6163-5590
Alexandra K FordDepartment of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.ORCID 0000-0001-8531-1243
Rudragouda ChannappanavarDepartment of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.ORCID 0000-0002-4067-278X

Funding

ZFC3H1 Regulation of Host Defense and Influenza A Virus PathogenesisP20GM103648 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI CHANNAPPANAVAR, RUDRAGOUDA · 2013 to 2022
$22.3M
Pilot Project Grant ProgramP30GM149368 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI LIN LIU · 2023 to 2026
$5.5M
Role of ERK1/2 signaling in SARS-CoV-2 -induced dysregulated immunity and lung pathology.R01HL165423 · NHLBI · OKLAHOMA STATE UNIVERSITY STILLWATER · PI Rudragouda Channappanavar · 2024 to 2026
$1.4M
Myeloid cell TRAF6 signaling in SARS-CoV-2-induced dysregulated lung immunityR21AI186028 · NIAID · OKLAHOMA STATE UNIVERSITY STILLWATER · PI CHANNAPPANAVAR, RUDRAGOUDA · 2024 to 2025
$406k
NHLBI NIH HHS R01 HL165423NIAID NIH HHS R21 AI186028NIGMS NIH HHS P20 GM103648NIGMS NIH HHS P30 GM149368NIH HHS NIH P20GM103648NIH HHS NIH R21AI186028NIH HHS P30GM149368NIH HHS P30GM149368-01 5321NIH HHS R01HL165423-01A1
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced impaired antiviral immunity and excessive inflammatory responses cause lethal pneumonia. However, the

Indexed as

COVID-19Membrane GlycoproteinsSARS-CoV-2Toll-Like Receptor 7AnimalsDisease Models, AnimalInterferonsInterferon Type ILungMiceMice, Inbred C57BLMice, KnockoutViral LoadVirus ReplicationInterferonsInterferon Type IMembrane GlycoproteinsTlr7 protein, mouseToll-Like Receptor 7inflammationinterferonmyeloid cellsSARS-CoV-2TLR7

Identifiers

PMID40162785
PMCPMC12090760

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.