Evidence map›Paper›PMID 40162742›Full record

ArticleFuture medicinal chemistry2025

Comparison between conventional, grinding, and microwave synthesis of methylpyrazoles as VEGFR-2/HSP90 dual inhibitors.

Ebtehal M Husseiny, Rana M Abdelnaby, Najla Altwaijry, Asmaa Saleh, Kurls E Anwer

Abstract readComparative Study
In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ebtehal M HusseinyPharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.ORCID 0000-0001-6594-1766
Rana M AbdelnabyPharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.ORCID 0000-0001-7634-2240
Najla AltwaijryDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.ORCID 0000-0001-6372-7141
Asmaa SalehDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Kurls E AnwerChemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt.ORCID 0000-0003-3017-8806

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimEmbracing structure extension and substitution variation, methylpyrazolones MATERIALS AND

methodsThe eco-friendly synthesis of the desired analogs was performed by conventional, grinding, and microwave-assisted methods.

resultsAll entities have been tested for their antitumor action against three carcinomas, whereas compounds

conclusionMolecular docking revealed strong interaction between the potent analogs and VEGFR-2/HSP90 active sites inspiring these congeners to be potential drug candidates in cancer treatment.

Indexed as

Antineoplastic AgentsHSP90 Heat-Shock ProteinsProtein Kinase InhibitorsPyrazolesVascular Endothelial Growth Factor Receptor-2ApoptosisCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMicrowavesMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsHSP90 Heat-Shock ProteinsKDR protein, humanProtein Kinase InhibitorsPyrazolesVascular Endothelial Growth Factor Receptor-2AnticancerHSP90methylpyrazolesynthesisVEGFR-2

Identifiers

PMID40162742
PMCPMC12506737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.