ArticleeLife2025
Inflammasomes primarily restrict cytosolic
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In one paragraph
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- RANKL inhibits macrophage proinflammatory Toll-like receptor 2 and 4 signaling and impairs killing of intracellular bacteria.ImmunoHorizons · 2026Article
- Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages.PLoS pathogens · 2026Article
- The role of NINJ1 in diseases.Cell death discovery · 2026Review
- Dual NLRC4 and non-canonical inflammasome signaling drives human GSDMD-mediated killing ofbioRxiv : the preprint server for biology · 2026Article
- Mechanism of GSDMD in the Pathogenesis ofTransboundary and emerging diseases · 2026Article
- Human non-canonical inflammasomes activate CASP3 to limit intracellularbioRxiv : the preprint server for biology · 2025Article
- Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens.Cell reports · 2025Article
- A tale of two caspases.eLife · 2025Article
- Viral-bacterial co-infections screen in vitro reveals molecular processes affecting pathogen proliferation and host cell viability.Nature communications · 2024Article
- Strategies of bacterial detection by inflammasomes.Cell chemical biology · 2024Review
- Article
Corrections and comments
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Authors and funding
11 authors.
Marisa S EganDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0001-6191-5552
Emily A O'RourkeDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0001-6736-7374
Shrawan Kumar MageswaranDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Biao ZuoInstitute of Structural Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0009-0005-9115-7170
Inna MartynyukInstitute of Structural Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Tabitha DemissieDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Emma N HunterDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0001-7549-9190
Antonia R BassDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0002-5623-0572
Yi-Wei ChangDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0003-2391-473X
Igor E BrodskyDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, United States.ORCID https://orcid.org/0000-0001-7970-872X
Sunny ShinDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0001-5214-9577
Funding
TRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0MInnate immune-mediated control of pulmonary Legionella pneumophila infectionR01AI118861 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHIN, SUNNY · 2016 to 2025
$4.6MDefining the mechanism and functions of RIPK1-induced cell death in anti-bacterial immune defenseR01AI139102 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2019 to 2023
$2.8MDefining the non-apoptotic role of Caspase-8 activity in anti-bacterial immune defenseR01AI128530 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2017 to 2021
$2.0MDefining human noncanonical inflammasome responses to Legionella pneumophilaR01AI123243 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHIN, SUNNY · 2016 to 2020
$2.0MDefining mechanisms of Casp1/11-independent death triggered by clinical Salmonella EnteritidisR21AI163596 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2022 to 2023
$447kTNF and caspase-8-mediated control of Legionella pneumophila infectionR21AI151476 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHIN, SUNNY · 2021 to 2022
$447kAmerican Heart Association 10.58275/aha.24pre1199554.pc.gr.190717Burroughs Wellcome Fund PATH AwardDavid and Lucile Packard Foundation 2019-69645National Institute of Allergy and Infectious Diseases AI118861National Institute of Allergy and Infectious Diseases AI123243National Institute of Allergy and Infectious Diseases AI128630National Institute of Allergy and Infectious Diseases AI139102National Institute of Allergy and Infectious Diseases AI151476National Institute of Allergy and Infectious Diseases AI163596National Science Foundation Graduate Research Fellowship Program DGE- 1321851National Science Foundation Graduate Research Fellowship Program DGE-1845298NIAID NIH HHS R01 AI118861NIAID NIH HHS R01 AI123243NIAID NIH HHS R01 AI128530NIAID NIH HHS R01 AI139102NIAID NIH HHS R21 AI151476NIAID NIH HHS R21 AI163596NIGMS NIH HHS T32 GM007229NIGMS NIH HHS T32GM07229Pennsylvania Department of Health FY19 Health Research Formula FundWellcome Trust
Abstract
PubMed holds no abstract for this paper.
Indexed as
CytosolInflammasomesMacrophagesSalmonella typhimuriumCaspase 1Caspases, InitiatorGasderminsHumansNeuronal Apoptosis-Inhibitory ProteinPhosphate-Binding ProteinsSalmonella InfectionsType III Secretion SystemsCASP4 protein, humanCaspase 1Caspases, InitiatorGasderminsGSDMD protein, humanInflammasomesNeuronal Apoptosis-Inhibitory ProteinPhosphate-Binding ProteinsType III Secretion Systemshumanhuman macrophagesimmunologyinfectious diseaseinflammasomesinflammationmicrobiologysalmonella enterica serovar typhimuriumSalmonella enterica serovar Typhimurium
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.