A Cytotoxic Indazole-based Gold(III) Carboxamide Pincer Complex Targeting DNA Through Dual Binding Modes of Groove Binding and Alkylation.

Rufaro Razuwika, Sheldon Sookai, Ruth Aronson, Mandeep Kaur, Orde Q Munro

Abstract read

In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rufaro RazuwikaMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, 1 Jan Smuts Avenue, Johannesburg, 2050, South Africa.ORCID https://orcid.org/0000-0001-9831-7759

Sheldon SookaiMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, 1 Jan Smuts Avenue, Johannesburg, 2050, South Africa.ORCID https://orcid.org/0000-0003-3360-7338

Ruth AronsonSchool of Molecular and Cell Biology, University of the Witwatersrand, 1 Jan Smuts Avenue, Johannesburg, 2050, South Africa.ORCID https://orcid.org/0000-0002-3030-9573

Mandeep KaurSchool of Molecular and Cell Biology, University of the Witwatersrand, 1 Jan Smuts Avenue, Johannesburg, 2050, South Africa.ORCID https://orcid.org/0000-0002-9757-4048

Orde Q MunroMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, 1 Jan Smuts Avenue, Johannesburg, 2050, South Africa.ORCID https://orcid.org/0000-0001-8979-6321

Funding

Centre for High Performance Computing CHEM1633National Research Foundation 116177National Research Foundation 64799South African Research Chairs Initiative of the Department of Science and InnovationUniversity of the Witwatersrand, Johannesburg 129920

6 · The paper itself

Abstract

Gold(III) complexes have garnered increasing attention in drug delivery due to their structural and mechanistic similarities to cisplatin. This study investigates an indazole-based gold(III) carboxamide pincer complex, [N

Indexed as

Antineoplastic AgentsCoordination ComplexesDNAGoldIndazolesAlkylationBinding SitesCell Line, TumorHT29 CellsHumansMCF-7 CellsAntineoplastic AgentsCoordination ComplexesDNAGoldIndazolescytotoxicityDFT simulationsDNAmetal chelatepincer ligand

Identifiers

PMID40162557

DOI10.1002/chem.202404345

PMCPMC12080311

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.