Evidence map›Paper›PMID 40162532›Full record

ArticleJournal of cosmetic dermatology2025

A Comparative Study on the Sensitivity of Establishing Melasma-Like Models in Different Strains of Mice.

Xiaojie Sun, Wenzhu Wang, Hedan Yang, Yunyao Liu, Hui Ding, Xiaoli Zhang, Xiuzhen Li, Siqi Tan, Xing Liu, Yin Yang and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaojie SunDepartment of Laser, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.ORCID https://orcid.org/0009-0004-0613-5448
Wenzhu WangDepartment of Laser, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Hedan YangDepartment of Laser, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Yunyao LiuJiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Department, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Hui DingDepartment of Laser, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Xiaoli ZhangDepartment of Laser, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.ORCID https://orcid.org/0000-0002-2155-3072
Xiuzhen LiDepartment of Laser, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Siqi TanDepartment of Laser, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Xing LiuDepartment of Laser, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Yin YangDepartment of Laser, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.ORCID https://orcid.org/0000-0001-7469-4218
Xu ChenJiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Department, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.ORCID https://orcid.org/0000-0003-4303-8116
Tong LinJiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Department, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.ORCID https://orcid.org/0000-0001-5336-9192

Funding

CAMS Innovation Fund for Medical Sciences CIFMS-2021-I2M-1-001Funds for Science and Technology Plan Projects in Jiangsu Province BE2023675National Natural Science Foundation of China 82103705
6 · The paper itself

Abstract

backgroundMelasma is a common disease that is difficult to treat, with no recognized animal model for mechanism research or drug screening.

objectivesTo develop a novel, standardized mouse model of melasma. MATERIALS AND

methodsThree different strains of mice (C57BL/6J, BALB/c, and KM) were used to create a melasma-like model across various body regions. The skin of the mice was removed on Day 28 and subjected to staining to examine histopathological changes. Data were analyzed using SPSS19.0 software.

resultsCompared with KM and BALB/c mice, C57BL/6J mice were identified as the ideal strain for demonstrating hyperpigmentation more sensitively. The head and ear were identified as more appropriate irradiation sites. Furthermore, a lower irradiation dose was determined to be appropriate for modeling.

conclusionThe C57BL/6J mouse model more accurately simulates the clinical phenotype of melasma.

Indexed as

Disease Models, AnimalMelanosisSkinAnimalsFemaleHumansMiceMice, Inbred BALB CMice, Inbred C57BLSpecies SpecificityBALB/c miceC57BL/6J miceKM micemelasmamouse model

Identifiers

PMID40162532
PMCPMC11956124

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.