Evidence map›Paper›PMID 40162453›Full record

ArticleBioinformation2024

Sathya Rathish Mohana Jeevanath, Manjari Venkatraman, Kalaivanan Karuppan, Abarna Balasubramani, Natarajan Mohan, Siva Annamalai

Abstract read
In one paragraph

Article in Bioinformation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sathya Rathish Mohana JeevanathDepartment of Nanju Maruthuvam, National Institute of Siddha, Dr.M.G.R Medical University, Chennai - 47, Tamil Nadu, India.
Manjari VenkatramanDepartment of Nanju Maruthuvam, National Institute of Siddha, Dr.M.G.R Medical University, Chennai - 47, Tamil Nadu, India.
Kalaivanan KaruppanDepartment of Siddha Medicine, Government Primary Health Centre, Perungattur, Tiruvannamalai - 604402, Tamil Nadu, India.
Abarna BalasubramaniDepartment of Nanju Maruthuvam, National Institute of Siddha, Dr.M.G.R Medical University, Chennai - 47, Tamil Nadu, India.
Natarajan MohanDepartment of Nanju Maruthuvam, National Institute of Siddha, Dr.M.G.R Medical University, Chennai - 47, Tamil Nadu, India.
Siva AnnamalaiDepartment of Clinical Research, Siddha Regional Research Institute (Central Council for Research in Siddha, Ministry of Ayush, Govt. of India) Kuyavarpalayam, Puducherry, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The second most common malignant tumour in women worldwide, cervical cancer seriously jeopardizes their health. It has been established that a high-risk Human papillomavirus (HPV) infection is the cause of cervical cancer. Cervical cancer is associated with several risk factors, including reproductive, behavioural and sexual characteristics. Many Siddha practitioners often prescribe Thanga uram (TU), a Siddha metallo-mineral formulation, for genito-urinary diseases, infertility, varicose veins and leucorrhoea. This study aims to evaluate the anti-cancer activity of "Thanga uram" against HeLa cell lines. Hela cell lines were used to assess the antiproliferative activity TU using the MTT assay and apoptosis by Annexin V flow cytometry. Thanga uram produced dose-dependent cytotoxic effects against HeLa cell lines with an LC50 value of 145.891µg/mL. Further investigation, using Annexin V flow cytometry, equivalently revealed the late apoptotic effect, with a percentage value of 28.15. Thus, the current study evaluates the effectiveness of Thanga Uram against cervical cancer.

Indexed as

annexin V flowcytometryAnti-cancerHeLa cell lineMTT assaysiddhathanga uram

Identifiers

PMID40162453
PMCPMC11953548

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.