ArticleFrontiers in endocrinology2025
Association of neutrophil to lymphocyte ratio with all-cause and cardiovascular mortality among individuals with kidney stone disease: result from NHANES, 2007-2018.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Safety and efficacy of a flexible and navigable suction ureteral access sheath vs. a conventional intelligent pressure-control sheath in retrograde intrarenal surgery for infection-related renal calculi.International urology and nephrology · 2026Trial
- Mortality following endoscopic management of symptomatic urolithiasis over a 10-year period: a single-centre retrospective cohort and case series.World journal of urology · 2026Article
- Association of Neutrophil-to-Lymphocyte Ratio With All-Cause and Cardiovascular Mortality Among Individuals With Depression: A Large-Scale Cohort Study.Brain and behavior · 2025Article
- The association between frailty index and all-cause mortality in US individuals with kidney stones: mediation by systemic immune-inflammation (SII) index.Urolithiasis · 2025Article
- Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome.Frontiers in nutrition · 2025Article
- Plant-based dietary patterns, micronutrient status and breast cancer outcomes: a joint analysis of UK Biobank and Chinese longitudinal healthy longevity survey.Frontiers in nutrition · 2025Article
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3 authors.
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Abstract
Background: The objective of this study is to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and all-cause as well as cause-specific mortality among patients with kidney stones, and to evaluate the capability of NLR as a predictor of mortality. Methods: This study included 2,995 patients with kidney stones from the NHANES database during the period from 2007 to 2018, and subsequently linked this data with the National Death Index. The relationship between NLR and mortality was analyzed using the Cox proportional hazards model and Kaplan-Meier survival curves. Additionally, restricted cubic spline (RCS) curves were employed to explore the dose-response relationship between NLR and mortality, while time-dependent ROC curves were utilized to assess the predictive capability of NLR for mortality. Finally, the mediating effect of estimated glomerular filtration rate (eGFR) on the relationship between NLR and mortality was also analyzed. Results: This study ultimately included 2,995 patients with kidney stones, with a median follow-up period of 74 months. A total of 395 deaths were recorded, of which 87 were attributed to cardiovascular diseases. An NLR cut-off of 3.62 was identified as significantly associated with survival outcomes using the 'maxstat' package and the principle of maximum rank statistics. The restricted cubic spline plot indicates a non-linear relationship between NLR and both all-cause mortality and cardiovascular mortality. After adjusting for relevant covariates, the Cox regression analysis demonstrated that, in comparison to the lower NLR group, the higher NLR group exhibited a 1.05-fold (HR 2.05, 95% CI 1.51-2.78, Conclusion: This study found that patients with kidney stones exhibiting a high NLR have a significantly increased risk of mortality in the U.S. population. Therefore, monitoring NLR may be important for the prognosis of patients with kidney stones.
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