ArticlemedRxiv : the preprint server for health sciences2025
Wildfire Smoke Exposure is Associated with Decreased Sperm Concentration and Total Motile Sperm Count.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: As wildfires become more prevalent, their impact on fertility warrants evaluation. We aimed to examine the impact of smoke exposure on semen analysis parameters of intrauterine insemination patients in the greater Seattle, WA area. We hypothesized that wildfire smoke exposure was associated with a decline in total motile sperm count. Design: Retrospective cohort study. Subjects: Patients undergoing fertility treatments at the University of Washington in 2018-2022. Exposure: Subjects were exposed to seasonal wildfire events in the fall of 2018, 2020, and 2022. Pre-exposure semen was a diagnostic fresh sample prior to each respective wildfire event while post-exposure semen was taken at time of intrauterine insemination (IUI) during the wildfire smoke exposure windows. All subjects acted as their own controls in a paired pre-post analysis. Main Outcome Measures: Primary outcome measure was total motile sperm count; secondary outcomes measures are semen volume, sperm concentration, total sperm count, total progressively motile sperm count, percent motile sperm, percent progressively motile sperm. Results: We identified 84 subjects who underwent IUI across the 2018 (n = 27), 2020 (n = 30), and 2022 (n = 27) wildfire smoke events. Median time between initial semen analysis and semen analysis for IUI was 4 months. We observed a decline in sperm concentration, total sperm count, total motile sperm count, and total progressively motile sperm count. We also observed an increase in percent progressively motile sperm. These trends did not differ across event year. Conclusions: Our results are consistent with a prior small study demonstrating that wildfire smoke exposure is associated with declines in sperm quality. These findings highlight the need for further research on the effects of wildfire smoke exposure on human sperm and fertility treatments, especially as smoke exposures are expected to increase with climate change.
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