Evidence map›Paper›PMID 40162284›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Childhood adversity is associated with longitudinal white matter changes after adulthood trauma.

Li Tianyi, Megan E Huibregtse, Timothy D Ely, Sanne J H van Rooij, Lauren A M Lebois, E Kate Webb, Tanja Jovanovic, Stacey L House, Steven E Bruce, Vishnu P Murty and 34 more

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Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

44 authors.

Li TianyiDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Megan E HuibregtseDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Timothy D ElyDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Lauren A M LeboisDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
E Kate WebbDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, 48202, USA.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, 63121, USA.
Vishnu P MurtyDepartment of Psychology, Temple University, Philadelphia, PA, 19121, USA.
Francesca L BeaudoinDepartment of Epidemiology, Brown University, Providence, RI, 02930, USA.
Xinming AnInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Thomas C NeylanDepartments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, 94143, USA.
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, 30332, USA.
Sarah D LinnstaedtInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Kenneth A BollenDepartment of Psychology and Neuroscience & Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Scott L RauchInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, 02478, USA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA.ORCID 0000-0001-7311-1121
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, MI, 48202, USA.
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.
Christopher W JonesDepartment of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, 08103, USA.
Brittany E PunchesDepartment of Emergency Medicine, Ohio State University College of Medicine, Columbus, OH, 43210, USA.
Lauren A HudakDepartment of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Jose L PascualDepartment of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Mark J SeamonDepartment of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Elizabeth M DatnerDepartment of Emergency Medicine, Jefferson Einstein hospital, Jefferson Health, Philadelphia, PA, 19141, USA.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, 48236, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Roland C MerchantDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Robert M DomeierDepartment of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, 48197, USA.
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, 01107, USA.
Brian J O'NeilDepartment of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, 48202, USA.
Paulina SergotDepartment of Emergency Medicine, McGovern Medical School at UTHealth, Houston, TX, 77030, USA.
Leon D SanchezDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
John F SheridanDivision of Biosciences, Ohio State University College of Dentistry, Columbus, OH, 43210, USA.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, 02115, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, 02115, USA.
Kerry J ResslerDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Samuel A McLeanDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Nathaniel G HarnettDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.

Funding

Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSPR01AG060477 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lea Tenenholz Grinberg, Thomas C Neylan · 2019 to 2026
$8.2M
Extracellular vesicles as biomarkers of trauma exposure and PTSD riskR01MH129495 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Tracy L Bale, Tanja Jovanovic · 2022 to 2026
$4.0M
Individual Variation in Effects of Traumatic Stress on Gray Matter MyelinR01MH115020 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI KAUFER, DANIELA, NEYLAN, THOMAS C · 2019 to 2023
$3.9M
Investigating Fear System Myelination in PTSD Using In Vivo and Post Mortem DataR01MH132617 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI HUBER, BERTRAND R, NEYLAN, THOMAS C · 2023 to 2025
$2.1M
Effect of TMS on PTSD Neuroimaging and Psychophysiological BiomarkersK01MH121653 · NIMH · EMORY UNIVERSITY · PI VAN ROOIJ, SANNE JH · 2020 to 2024
$894k
Multimodal characterization of affective visual processing in the early aftermath of traumaK01MH129828 · NIMH · MCLEAN HOSPITAL · PI Nathaniel G Harnett · 2023 to 2026
$719k
Characterizing the Neurobiology of Pathological Dissociation: Mechanisms of Face Perception and Self Referential ProcessingK01MH118467 · NIMH · MCLEAN HOSPITAL · PI LEBOIS, LAUREN ANN MCDONOUGH · 2019 to 2022
$679k
Sex differences in traumatic brain injury: Neural circuit mediators of overlapping stress and physical effectsF32MH134528 · NIMH · EMORY UNIVERSITY · PI HUIBREGTSE, MEGAN E · 2023 to 2024
$158k
NIA NIH HHS R01 AG060477NIMH NIH HHS F32 MH134528NIMH NIH HHS K01 MH118467NIMH NIH HHS K01 MH121653NIMH NIH HHS K01 MH129828NIMH NIH HHS R01 MH115020NIMH NIH HHS R01 MH129495NIMH NIH HHS R01 MH132617NIMH NIH HHS U01 MH110925
6 · The paper itself

Abstract

Background: Childhood adversity is associated with susceptibility to posttraumatic stress disorder (PTSD) in adulthood. Both PTSD and adverse experiences in childhood are linked to disrupted white matter microstructure, yet the role of white matter as a potential neural mechanism connecting childhood adversity to PTSD remains unclear. The present study investigated the potential moderating role of previous childhood adversity on longitudinal changes in white matter microstructures and posttraumatic stress symptoms following a recent traumatic event in adulthood. Methods: As part of the AURORA Study, 114 recent trauma survivors completed diffusion weighted imaging at 2-weeks and 6-months after exposure. Participants reported on prior childhood adversity and PTSD symptoms at 2-weeks, 6-months, and 12-months post-trauma. We performed both region-of-interest (ROI) and whole-brain correlational tractography analyses to index associations between white matter microstructure changes and prior adversity. Results: Whole-brain correlational tractography revealed that greater childhood adversity moderated the changes in quantitative anisotropy (QA) over time across threat and visual processing tracts including the cingulum bundle and inferior fronto-occipital fasciculus (IFOF). Further, QA changes within cingulum bundle, IFOF, and inferior longitudinal fasciculus were associated with changes in PTSD symptoms between 2-weeks and 6-months. Conclusions: Our findings suggest temporal variability in threat and visual white matter tracts may be a potential neural pathway through which childhood adversity confers risk to PTSD symptoms after adulthood trauma. Future studies should take the temporal properties of white matter into consideration to better understand the neurobiology of childhood adversity and PTSD.

Indexed as

Childhood AdversityDiffusion Tensor ImagingPTSDWhite Matter

Identifiers

PMID40162284
PMCPMC11952606

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