Evidence map›Paper›PMID 40162225›Full record

ArticleResearch square2025

The role of medullary astrocytes in breathing and arousal: insights into glial regulation of respiratory function.

Jan Marino Ramirez, Luiz Oliveira, Nicole Miranda, Hyun-Kyoung Lim, Liza Severs, Ana Takakura, Thiago Moreira, Franck Kalume

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jan Marino RamirezSeattle Children's Research Institute.ORCID 0000-0002-5626-3999
Luiz OliveiraUniversidade de São Paulo.
Nicole MirandaSeattle Children's Research Center.ORCID 0000-0003-0202-1027
Hyun-Kyoung LimHyun-Kyoung.ORCID 0000-0003-1818-420X
Liza SeversSeattle Children's Research Institute, The University of Wasington.ORCID 0000-0002-9470-8186
Ana TakakuraUniversidade de São Paulo.
Thiago MoreiraUniversity of São Paulo.
Franck KalumeSeattle Children's Research Institute.

Funding

Unraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3M
Unraveling the dynamic mechanisms underlying opioid respiratory depressionR01HL144801 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2019 to 2026
$5.2M
Neuroglial interactions underlying the generation of the sighR01HL151389 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAMIREZ, JAN M. · 2020 to 2023
$3.2M
Mechanisms underlying neuromodulation-induced breathing instabilityR01HL107084 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAMIREZ, JAN M. · 2011 to 2014
$2.6M
NHLBI NIH HHS R01 HL107084NHLBI NIH HHS R01 HL126523NHLBI NIH HHS R01 HL144801NHLBI NIH HHS R01 HL151389
6 · The paper itself

Abstract

Astrocytes play vital roles in regulating brain states across organisms. Specifically, they serve several roles in regulating breathing behaviors and associated brain states, including facilitating transitions between phases of breathing by sensing small changes in O

Indexed as

central chemoreceptionpreBötzinger complexpurinergicsigh

Identifiers

PMID40162225
PMCPMC11952647

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.