ArticleResearch square2025
Energetic diversity in retinal ganglion cells is modulated by neuronal activity and correlates with resilience to degeneration.
Zelun Wang, Christopher Zhao, Shelly Xu, Sean McCracken, Rajendra S Apte, Philip R Williams
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Zelun WangJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-3768-6934 Christopher ZhaoJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shelly XuJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sean McCrackenJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
Rajendra S ApteJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-2281-2336 Philip R WilliamsJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
Funding
WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Steven Bassnett · 1985 to 2026
$18.4MVulnerable and Resilient Cells in Retinal DegenerationR01EY012543 · NEI · WASHINGTON UNIVERSITY · PI SHIMING CHEN, Philip Raymond Williams · 2000 to 2026
$12.2MResearch Training Program in the Vision SciencesT32EY013360 · NEI · WASHINGTON UNIVERSITY · PI SHIMING CHEN, Daniel Kerschensteiner · 2000 to 2026
$5.6MActivity-related mechanisms of selective retinal ganglion cell resilience and axon regenerationR01EY036111 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Nicholas Minh Abell Tran · 2024 to 2026
$2.2MIdentifying and leveraging strategies of inherently resilient retinal neurons to treat degenerationR01EY032908 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 2022 to 2026
$1.9MKinase regulators of retinal ganglion cell survival and axon regenerationR01EY035684 · NEI · BOSTON CHILDREN'S HOSPITAL · PI ZHIGANG HE, Philip Raymond Williams · 2024 to 2026
$1.9MNEI NIH HHS P30 EY002687NEI NIH HHS R01 EY012543NEI NIH HHS R01 EY032908NEI NIH HHS R01 EY035684NEI NIH HHS R01 EY036111NEI NIH HHS T32 EY013360
6 · The paper itselfAbstract
Neuronal function requires high energy expenditure that is likely customized to meet specific signaling demands. However, little is known about diversity of metabolic homeostasis among divergently-functioning types of neurons. To this end, we examined retinal ganglion cells (RGCs), a population of closely related, yet electrophysiologically distinct excitatory projection neurons. Using
Identifiers
PMID40162221
PMCPMC11952644
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390