Evidence map›Paper›PMID 40162211›Full record

ArticleResearch square2025

Bipolar and schizophrenia risk gene

You-Kyung Lee, Cong Xiao, Xiaoting Zhou, Le Wang, Meghan G McReynolds, Zhiping Wu, Eric Purisic, Henry Kim, Xianting Li, Zhiping Pang and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

You-Kyung LeeDepartment of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-0818-0080
Cong XiaoDepartment of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Xiaoting ZhouDepartment of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Le WangChild Health Institute of New Jersey and Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA.
Meghan G McReynoldsDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zhiping WuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Eric PurisicDepartment of Neuroscience, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Henry KimDepartment of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Xianting LiDepartment of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-3153-0931
Zhiping PangChild Health Institute of New Jersey and Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA.ORCID 0000-0002-6183-1233
Jinye DaiDepartment of Pharmacological Sciences, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Junmin PengDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-0472-7648
Nan YangDepartment of Neuroscience, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0003-3663-1288
Zhenyu YueDepartment of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0001-8730-8515

Funding

Neuronal Autophagy: a Cell-Autonomous Protection MechanismR01NS060123 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zhenyu Yue · 2008 to 2026
$9.2M
Assay and Data Generation Center (ADGC) for the Model of iPSC-derived Neurons for NPD (MiNND)RM1MH133065 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Jubao Duan, Jennifer Gladys Mulle · 2023 to 2026
$7.0M
Cellular consequences and convergent biology of schizophrenia-associated rare variants in the diverse GPC cohortR01MH131296 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI HART, RONALD P, MULLE, JENNIFER GLADYS · 2022 to 2024
$3.7M
Loss-of-Function Analyses of SETD1A in Human Neural ModelsR01MH125528 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MING, GUO-LI, PANG, ZHIPING P. · 2021 to 2025
$3.2M
Determining Selective Autophagy Kinase in Modulating Neurotoxicity in Huntington's Disease ModelR01NS117590 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YUE, ZHENYU · 2020 to 2024
$2.3M
Determining neuroprotective autophagy functions using different types of human neuronsR21AG067570 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YANG, NAN, YUE, ZHENYU · 2020 to 2020
$466k
NIA NIH HHS R21 AG067570NIMH NIH HHS R01 MH125528NIMH NIH HHS R01 MH131296NIMH NIH HHS RM1 MH133065NINDS NIH HHS R01 NS060123NINDS NIH HHS R01 NS117590
6 · The paper itself

Abstract

Human genomic studies have identified protein-truncating variants in

Identifiers

PMID40162211
PMCPMC11952666

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.