ArticleResearch square2025
Sex differences in response to violence: Role of salience network expansion and connectivity on depression.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Violence is a major risk factor for depression across development. Depression quickly worsens during early adolescence, however, and especially among females, who experience worse depression following threats than males. This may be because they perceive future threats as less controllable. Evidence suggests that features of the salience network may serve as particularly critical mechanisms explaining sex differences on depression in response to threat, as those with depressive disorders have more expansive salience networks than controls, and threatening experiences result in the brain utilizing more tissue for fear generation in rodent models. Using a longitudinal sample of 220 adolescents ages 14-18 from the Chicago area, we test if salience network expansion and connectivity explain the differential impact of violence on depression across the sexes. We found that the association between violence and depression was greater for females than males
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