Evidence map›Paper›PMID 40162127›Full record

ArticlePRX life2024

Mesoscale molecular assembly is favored by the active, crowded cytoplasm.

Tong Shu, Gaurav Mitra, Jonathan Alberts, Matheus P Viana, Emmanuel D Levy, Glen M Hocky, Liam J Holt

Abstract read
In one paragraph

Article in PRX life, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Allostery in Biomolecular Condensates.Journal of molecular biology · 2026
    Review
  6. Accelerated Ostwald Ripening by Chemical Activity.Journal of the American Chemical Society · 2025
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Tong ShuInstitute for Systems Genetics, New York University Langone Medical Center, New York, New York 10016, USA.
Gaurav MitraDepartment of Chemistry, New York University, New York, New York 10003, USA.
Jonathan AlbertsInstitute for Systems Genetics, New York University Langone Medical Center, New York, New York 10016, USA.
Matheus P VianaAllen Institute for Cell Science, Seattle, Washington 98109, USA.
Emmanuel D LevyDepartment of Molecular and Cellular Biology, University of Geneva, 1211 Geneva 4, Switzerland.
Glen M HockyDepartment of Chemistry, New York University, New York, New York 10003, USA.
Liam J HoltInstitute for Systems Genetics, New York University Langone Medical Center, New York, New York 10016, USA.

Funding

The Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal DementiaR01NS127186 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOLT, LIAM J, PHATNANI, HEMALI · 2021 to 2025
$8.2M
Cancer under pressure: Mechanisms of adaptation to compressive stressR37CA240765 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOLT, LIAM J · 2019 to 2025
$3.2M
Harnessing simulations to uncover molecular mechanisms of mechanosensingR35GM138312 · NIGMS · NEW YORK UNIVERSITY · PI Glen Hocky · 2020 to 2026
$3.0M
Tools to probe the biophysical properties of cellsR01GM132447 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOLT, LIAM J · 2019 to 2022
$2.1M
NCI NIH HHS R37 CA240765NIGMS NIH HHS R01 GM132447NIGMS NIH HHS R35 GM138312NINDS NIH HHS R01 NS127186
6 · The paper itself

Abstract

The mesoscale organization of molecules into membraneless biomolecular condensates is emerging as a key mechanism of rapid spatiotemporal control in cells. Principles of biomolecular condensation have been revealed through

Indexed as

Actin DynamicsActive MatterMacromolecular CrowdingPhase separation

Identifiers

PMID40162127
PMCPMC11952695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.