Evidence map›Paper›PMID 40162116›Full record

ArticleJID innovations : skin science from molecules to population health2025

IGF2BP3 As a Prognostic Biomarker and Regulator of Metastasis in Merkel Cell Carcinoma.

Yajie Yang, Jiwei Gao, Hao Shi, Harri Sihto, Sami Kilpinen, François Vilcot, Libuse Janská, Jakob Jeschonneck, Todor Cvetanovic, Anders Höög and 6 more

Abstract read
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yajie YangDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Jiwei GaoDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Hao ShiDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Harri SihtoDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Sami KilpinenMolecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland.
François VilcotDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Libuse JanskáDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Jakob JeschonneckDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Todor CvetanovicDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Anders HöögDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Jan SiarovDepartment of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
John PaoliDepartment of Dermatology and Venereology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
C Christofer JuhlinDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Lisa VillabonaDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Catharina LarssonDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.
Weng-Onn LuiDepartment of Oncology-Pathology, Karolinska Institutet and BioClinicum, Karolinska University Hospital, Solna, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is an aggressive skin cancer with frequent metastasis; however, effective treatment options for advanced disease are often lacking. In this study, we investigated the clinical significance and functional impact of IGF2 mRNA-binding protein 3 (IGF2BP3) in MCC. Our results revealed elevated IGF2BP3 expression in metastases compared to that in primary tumors. High

Indexed as

BiomarkerIGF2BP3Merkel cell carcinomaMetastasis

Identifiers

PMID40162116
PMCPMC11951866

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.