ArticleRegenerative therapy2025
Adenovirus mediated gene delivery of α-calcitonin gene-related peptide facilitates osseointegration of implant in ovariectomized rat.
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Bioinspired Engineering of Streamlined Skeletal Interoception: Neural Bioprinted Piezoelectric Scaffolds for Neuro-Vascularized Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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7 authors.
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Abstract
Background: Osteoporosis, which adversely affected osseointegration of dental implants, became prevalent with the entry of ageing era. Recent studies indicated that α-calcitonin gene-related peptide (α-CGRP) played a role in modulating osteoporosis. However, due to the plasma half-life of α-CGRP being estimated at merely 7-10 min, it was difficult to utilize a conventional method that administered sufficient α-CGRP to the implant site. This present study aimed to investigate the efficacy of an α-CGRP transgene in promoting implant osseointegration in ovariectomized (OVX) rats. Method: The osteoporosis rat model was established through bilateral ovariectomy, following which the subjects were categorized into three distinct groups: the α-CGRP transgene group, the empty virus vector group, and the blank control group. Ad-CGRP-EGFP was locally administered into the bone defect site prior to implant placement in the OVX rats. 7 and 28 days after implantation, the femurs were isolated for molecular and histological analyses, micro-CT analysis and biomechanical test. Result: Bone marrow stromal cells (BMSCs) transduced with Ad-CGRP-EGFP could continuously express α-CGRP more than 28 days in vitro. Successful transgene expression was confirmed through cryosectioning and Western blot analysis 7 days after implantation in vivo. The results indicated a substantial decrease in the quantity of TRAP + cells in the α-CGRP transgene group. Additionally, quantitative real-time RT-PCR and Western blot analysis revealed a significant elevation in the expression levels of Runx2 and ALP, coupled with a notable reduction in the expression of cathepsin K and RANKL Conclusion: This study implied a great therapeutic potential of α-CGRP in osseointegration of titanium implants in OVX-relative osteoporosis rats, offering valuable insights for guiding bone regeneration strategies under osteoporotic conditions.
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