Evidence map›Paper›PMID 40162018›Full record

ArticleRegenerative therapy2025

A human iPSC-Derived myelination model for investigating fetal brain injuries.

Tsuyoshi Hiraiwa, Shoko Yoshii, Jiro Kawada, Tohru Sugawara, Tomoyuki Kawasaki, Shinsuke Shibata, Tomoko Shindo, Keiya Fujimori, Akihiro Umezawa, Hidenori Akutsu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tsuyoshi HiraiwaDepartment of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan.
Shoko YoshiiCenter for Regenerative Medicine, National Center for Child Health and Development, Tokyo, Japan.
Jiro KawadaJiksak Bioengineering, Inc., Kanagawa, Japan.
Tohru SugawaraCenter for Regenerative Medicine, National Center for Child Health and Development, Tokyo, Japan.
Tomoyuki KawasakiCenter for Regenerative Medicine, National Center for Child Health and Development, Tokyo, Japan.
Shinsuke ShibataElectron Microscope Laboratory, Keio University School of Medicine, Tokyo, Japan.
Tomoko ShindoElectron Microscope Laboratory, Keio University School of Medicine, Tokyo, Japan.
Keiya FujimoriDepartment of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan.
Akihiro UmezawaCenter for Regenerative Medicine, National Center for Child Health and Development, Tokyo, Japan.
Hidenori AkutsuCenter for Regenerative Medicine, National Center for Child Health and Development, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral white matter injuries, such as periventricular leukomalacia, are major contributors to neurodevelopmental impairments in preterm infants. Despite the clinical significance of these conditions, human-relevant models for studying fetal brain development and injury mechanisms remain limited. This study introduces a human iPSC-derived myelination model developed using a microfluidic device. The platform combines spinal cord-patterned neuronal and oligodendrocyte spheroids to recapitulate axon-glia interactions and myelination processes

Indexed as

Cerebral white matter injuryInduced pluripotent stem cellsmicrofluidic modelMyelinationOligodendrocyte developmentPeriventricular leukomalacia

Identifiers

PMID40162018
PMCPMC11953958

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.