Evidence map›Paper›PMID 40161983›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2025

Translational network neuroscience: Nine roadblocks and possible solutions.

Lucius S Fekonja, Stephanie J Forkel, Dogu Baran Aydogan, Pantelis Lioumis, Alberto Cacciola, Carolin Weiß Lucas, Jacques-Donald Tournier, Francesco Vergani, Petra Ritter, Robert Schenk and 3 more

Abstract read
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lucius S FekonjaDepartment of Neurosurgery, Charité - University Hospital, Berlin, Germany.ORCID https://orcid.org/0000-0003-1973-4410
Stephanie J ForkelDonders Centre for Cognition, Radboud University, Thomas van Aquinostraat 4, 6525 GD Nijmegen, the Netherlands.ORCID https://orcid.org/0000-0003-0493-0283
Dogu Baran AydoganA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0002-7840-3294
Pantelis LioumisDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.ORCID https://orcid.org/0000-0003-2016-9199
Alberto CacciolaBrain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0001-9412-4116
Carolin Weiß LucasUniversity Hospital and Medical Faculty of the University of Cologne, Center for Neurosurgery, Cologne, Germany.
Jacques-Donald TournierDepartment of Perinatal Imaging and Health, School of Biomedical Engineering & Imaging Sciences, King's College London, United Kingdom.ORCID https://orcid.org/0000-0001-5591-7383
Francesco VerganiDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, Department of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, United Kingdom.
Petra RitterCharité - Universitätsmedizin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Einstein Center for Neurosciences, Charitéplatz 1, 10117 Berlin, Germany.ORCID https://orcid.org/0000-0002-4643-4782
Robert SchenkDepartment of Neurosurgery, Charité - University Hospital, Berlin, Germany.
Boshra ShamsDepartment of Neurosurgery, Charité - University Hospital, Berlin, Germany.ORCID https://orcid.org/0000-0002-1290-6630
Melina Julia EngelhardtDepartment of Neurosurgery, Charité - University Hospital, Berlin, Germany.ORCID https://orcid.org/0000-0002-2921-6329
Thomas PichtDepartment of Neurosurgery, Charité - University Hospital, Berlin, Germany.ORCID https://orcid.org/0000-0002-8630-1466

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Translational network neuroscience aims to integrate advanced neuroimaging and data analysis techniques into clinical practice to better understand and treat neurological disorders. Despite the promise of technologies such as functional MRI and diffusion MRI combined with network analysis tools, the field faces several challenges that hinder its swift clinical translation. We have identified nine key roadblocks that impede this process: (a) theoretical and basic science foundations; (b) network construction, data interpretation, and validation; (c) MRI access, data variability, and protocol standardization; (d) data sharing; (e) computational resources and expertise; (f) interdisciplinary collaboration; (g) industry collaboration and commercialization; (h) operational efficiency, integration, and training; and (i) ethical and legal considerations. To address these challenges, we propose several possible solution strategies. By aligning scientific goals with clinical realities and establishing a sound ethical framework, translational network neuroscience can achieve meaningful advances in personalized medicine and ultimately improve patient care. We advocate for an interdisciplinary commitment to overcoming translational hurdles in network neuroscience and integrating advanced technologies into routine clinical practice.

Indexed as

ConnectomicsNetwork neurosciencePatientsPersonalized medicineTranslational medicine

Identifiers

PMID40161983
PMCPMC11949582

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.