ArticleNetwork neuroscience (Cambridge, Mass.)2025
Functional connectotomy of a whole-brain model reveals tumor-induced alterations to neuronal dynamics in glioma patients.
Article in Network neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Digital Twins in Neuro-Oncology: A Systematic Review of Current Implementations, Technical Strategies, and Clinical Applications.Radiology. Imaging cancer · 2026Pooled it
- nTMS-determined cortical excitability is associated with overall survival in patients with motor-eloquent glioblastoma.Journal of neuro-oncology · 2026Article
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5 authors.
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Abstract
Brain tumors can induce pathological changes in neuronal dynamics that are reflected in functional connectivity measures. Here, we use a whole-brain modeling approach to investigate pathological alterations to neuronal activity in glioma patients. By fitting a Hopf whole-brain model to empirical functional connectivity, we investigate glioma-induced changes in optimal model parameters. We observe considerable differences in neuronal dynamics between glioma patients and healthy controls, both on an individual and population-based level. In particular, model parameter estimation suggests that local tumor pathology causes changes in brain dynamics by increasing the influence of interregional interactions on global neuronal activity. Our approach demonstrates that whole-brain models provide valuable insights for understanding glioma-associated alterations in functional connectivity.
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