Evidence map›Paper›PMID 40161978›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2025

Tangent space functional reconfigurations in individuals at risk for alcohol use disorder.

Mahdi Moghaddam, Mario Dzemidzic, Daniel Guerrero, Mintao Liu, Jonathan Alessi, Martin H Plawecki, Jaroslaw Harezlak, David A Kareken, Joaquín Goñi

Abstract read
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Mahdi MoghaddamEdwardson School of Industrial Engineering, Purdue University, West Lafayette, IN, USA.
Mario DzemidzicDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Daniel GuerreroEdwardson School of Industrial Engineering, Purdue University, West Lafayette, IN, USA.
Mintao LiuEdwardson School of Industrial Engineering, Purdue University, West Lafayette, IN, USA.
Jonathan AlessiDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Martin H PlaweckiIndiana Alcohol Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Jaroslaw HarezlakIndiana Alcohol Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
David A KarekenDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Joaquín GoñiEdwardson School of Industrial Engineering, Purdue University, West Lafayette, IN, USA.

Funding

Translational Research and Science Education (OUT)P60AA007611 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Nicholas Joseph Grahame · 2003 to 2026
$45.5M
Functional connectivity reconfigurations in risk for alcohol use disordersR01AA029607 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI Mario Dzemidzic, DAVID A. KAREKEN · 2022 to 2026
$2.7M
Comprehensive White-matter Microstructure-informed Analytical Methods to Elucidate Neurobiological Mechanisms of Sports-related Concussion (SRC)R01NS112303 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI HAREZLAK, JAROSLAW, WU, YU-CHIEN · 2020 to 2024
$2.3M
Influence of the College Football Athletes' Cumulative Head Impact Exposure (HIE) on the mTBI incidence and post-mTBI health outcomesR01NS126449 · NINDS · TRUSTEES OF INDIANA UNIVERSITY · PI HAREZLAK, JAROSLAW, STEMPER, BRIAN D · 2022 to 2025
$1.4M
Limbic-Executive Network Transitions in Alcohol Use DisorderR21AA029614 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI KAREKEN, DAVID A. · 2021 to 2022
$430k
NIAAA NIH HHS P60 AA007611NIAAA NIH HHS R01 AA029607NIAAA NIH HHS R21 AA029614NINDS NIH HHS R01 NS112303NINDS NIH HHS R01 NS126449
6 · The paper itself

Abstract

Human brain function dynamically adjusts to ever-changing stimuli from the external environment. Studies characterizing brain functional reconfiguration are, nevertheless, scarce. Here, we present a principled mathematical framework to quantify brain functional reconfiguration when engaging and disengaging from a stop signal task (SST). We apply tangent space projection (a Riemannian geometry mapping technique) to transform the functional connectomes (FCs) of 54 participants and quantify functional reconfiguration using the correlation distance of the resulting tangent-FCs. Our goal was to compare functional reconfigurations in individuals at risk for alcohol use disorder (AUD). We hypothesized that functional reconfigurations when transitioning to/from a task would be influenced by family history of AUD (FHA) and other AUD risk factors. Multilinear regression models showed that engaging and disengaging functional reconfiguration were associated with FHA and recent drinking. When

Indexed as

Family historyFunctional connectivityRegularizationRest-task and task-rest fMRIRiemannian geometry

Identifiers

PMID40161978
PMCPMC11949615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.