Evidence map›Paper›PMID 40161951›Full record

ArticleACS central science2025

Thioesters Support Efficient Protein Biosynthesis by the Ribosome.

Alexandra D Kent, Jacob G Robins, Isaac J Knudson, Jessica T Vance, Alexander C Solivan, Noah X Hamlish, Katelyn A Fitzgerald, Alanna Schepartz, Scott J Miller, Jamie H D Cate

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexandra D KentDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Jacob G RobinsDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Isaac J KnudsonDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Jessica T VanceDepartment of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States.ORCID https://orcid.org/0009-0002-6300-9646
Alexander C SolivanDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Noah X HamlishDepartment of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States.
Katelyn A FitzgeraldDepartment of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States.
Alanna SchepartzDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID https://orcid.org/0000-0003-2127-3932
Scott J MillerDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID https://orcid.org/0000-0001-7817-1318
Jamie H D CateDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID https://orcid.org/0000-0001-5965-7902

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thioesters are critical chemical intermediates in numerous extant biochemical reactions and are invoked as key reagents during prebiotic peptide synthesis on an evolving Earth. Here we asked if a thioester could replace the native oxo-ester in acyl-tRNA substrates during protein biosynthesis by the ribosome. We prepared 3'-thio-3'-deoxyadenosine triphosphate in 10 steps from xylose and demonstrated that it is an effective substrate for the

Identifiers

PMID40161951
PMCPMC11950863

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.