Evidence map›Paper›PMID 40161936›Full record

ArticleBioImpacts : BI2025

A potential mechanism for tau protein modulating in schizophrenia with transcranial direct current stimulation intervention: A randomized controlled trial.

Ali Reza Shafiee-Kandjani, Farnaz Chalabianloo, Sara Farhang, Dariush Shanehbandi, Behzad Shalchi

Abstract read
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Article in BioImpacts : BI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ali Reza Shafiee-KandjaniDepartment of Psychiatry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-3045-2644
Farnaz ChalabianlooResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0009-0008-8827-452X
Sara FarhangResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0001-8552-138X
Dariush ShanehbandiImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-9449-0607
Behzad ShalchiResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0001-5918-2919

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Schizophrenia involves cognitive deficits, including working memory impairments. Researches indicate tau protein abnormalities may contribute to cognitive dysfunction in schizophrenia. While transcranial direct current stimulation (tDCS) shows promise in improving cognitive function, its effects on tau protein and working memory in schizophrenia remain unclear. Methods: Forty participants were randomly assigned to receive either tDCS or sham treatment in this randomized clinical trial. The tDCS group received anodal stimulation over the left dorsolateral prefrontal cortex (DLPFC) for 20 minutes, while the sham group received a placebo. Serum tau levels and working memory were assessed before and after using ELISA and the digit span task. Results: The results showed that the tDCS group had a significantly higher increase in phosphorylated tau protein serum levels compared to the sham group (5.53 ± 3.67 vs. 1.49 ± 3.90, Conclusion: These findings reveal the tDCS impact on tau markers, shedding light on the disorder's molecular pathways and sex influences. Enhanced memory, linked to tau changes, suggests its potential as a treatment indicator.

Indexed as

Cognitive functionSchizophreniaTau proteinTranscranial direct current stimulationWechsler Adult Intelligent ScaleWorking memory

Identifiers

PMID40161936
PMCPMC11954739

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.