Evidence map›Paper›PMID 40161844›Full record

ArticlebioRxiv : the preprint server for biology2025

A standardized, open-source, portable model for noninvasive joint injury in mice.

Michael D Newton, Lindsey Lammlin, Sofia Gonzalez-Nolde, Scarlet Howser, Isabelle Smith, Luke Stasikelis, Alexander J Knights, RE-JOIN Consortium Investigators, Tristan Maerz

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Michael D NewtonORCID 0000-0003-1262-0613
Lindsey LammlinORCID 0000-0003-4126-8292
Sofia Gonzalez-NoldeORCID 0009-0001-6801-1270
Scarlet Howser
Isabelle Smith
Luke Stasikelis
Alexander J KnightsORCID 0000-0001-8402-2212
RE-JOIN Consortium Investigators
Tristan MaerzORCID 0000-0002-4523-6012

Funding

Fibrosis, inflammation, and osteophyte formation in post-traumatic osteoarthritisK99AR081894 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KNIGHTS, ALEXANDER JOHN · 2023 to 2024
$206k
NIAMS NIH HHS K99 AR081894
6 · The paper itself

Abstract

Preclinical models of osteoarthritis (OA) are crucial for the study of disease mechanisms and for the development of critically-needed disease-modifying therapeutics. While surgical OA models, such as the destabilization of the medial meniscus (DMM), have been the gold standard in the field for decades, noninvasive joint loading-based models have increased in popularity and utility. To facilitate standardization of the noninvasive anterior cruciate ligament rupture (ACLR) model in mice, we present the

Identifiers

PMID40161844
PMCPMC11952444

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.