Evidence map›Paper›PMID 40161833›Full record

ArticlebioRxiv : the preprint server for biology2025

Transcriptomic and chromatin accessibility profiling unveils new regulators of heat hormesis in

Hsin-Yun Chang, Sarah E McMurry, Sicheng Ma, Christian A Mansour, Sophia Marie T Schwab, Charles G Danko, Siu Sylvia Lee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Hsin-Yun ChangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America.
Sarah E McMurryDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America.
Sicheng MaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America.
Christian A MansourDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America.
Sophia Marie T SchwabDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America.
Charles G DankoDepartment of Biomedical Science, Cornell University, Ithaca, New York, United States of America.
Siu Sylvia LeeDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America.

Funding

Systematic Analysis of C elegans Longevity DeterminantsR01AG024425 · NIA · CORNELL UNIVERSITY ITHACA · PI Siu Sylvia Lee · 2004 to 2026
$8.5M
Investigate the Transcriptional Co-factors of DAF-16/FOXO in C. elegansR56AG024425 · NIA · CORNELL UNIVERSITY · PI LEE, SIU SYLVIA · 2009 to 2009
$383k
NIA NIH HHS R01 AG024425NIA NIH HHS R56 AG024425
6 · The paper itself

Abstract

Heat hormesis describes the beneficial adaptations from transient exposure to mild heat stress, which enhances stress resilience and promotes healthy aging. It is thought to be the underlying basis of popular wellness practices like sauna therapy. Despite extensive documentation across species, the molecular basis of the long-term protective effects of heat hormesis remain poorly understood. This study bridges that critical gap through a comprehensive multiomic analysis, providing key insights into the transcriptomic and chromatin accessibility landscapes throughout a heat hormesis regimen adapted in

Indexed as

Caenorhabditis eleganschromatin accessibility profilingdose-dependent responseHeat hormesisstress adaptationtranscriptomic profiling

Identifiers

PMID40161833
PMCPMC11952391

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.