Evidence map›Paper›PMID 40161820›Full record

ArticlebioRxiv : the preprint server for biology2025

Muscle-specific increased expression of

Felipe de Souza Leite, Matthias R Lambert, Tracy Yuanfan Zhang, James R Conner, Joao A Paulo, Sheldon Furtado Oliveira, Sanjukta Thakurta, Jennifer Bowles, Emanuela Gussoni, Steven P Gygi and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Felipe de Souza LeiteDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2493-8872
Matthias R LambertDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8300-3124
Tracy Yuanfan ZhangDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4325-8533
James R ConnerDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8886-1475
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4291-413X
Sheldon Furtado OliveiraDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0006-4245-4985
Sanjukta ThakurtaDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Jennifer BowlesDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Emanuela GussoniDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9915-3677
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Jeffrey J WidrickDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-5597-1141
Louis M KunkelDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6126-0242

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Modulation of Jagged1/Pitpna in DMD as a means of therapyR01AR064300 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI KUNKEL, LOUIS M · 2014 to 2023
$3.9M
A new multi-pathway kinase activity assay applied to compound library screening in cancer biologyR00CA273170 · NCI · UNIVERSITY OF VIRGINIA · PI ZHANG, TIAN · 2023 to 2025
$747k
Unveiling the molecular mechanisms in TPM3-related myopathy and therapiesK99AR080197 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI LAMBERT, MATTHIAS · 2022 to 2023
$212k
NCI NIH HHS R00 CA273170NIAMS NIH HHS K99 AR080197NIAMS NIH HHS R01 AR064300NICHD NIH HHS P50 HD105351
6 · The paper itself

Abstract

Therapeutic strategies for Duchenne Muscular Dystrophy (DMD) will likely require complementary approaches. One possibility is to explore genetic modifiers that improve muscle regeneration and function. The beneficial effects of the overexpression of Jagged-1 were described in escaper golden retriever muscular dystrophy (GRMD) dogs that had a near-normal life and validated in dystrophin-deficient zebrafish (1). To clarify the underlying biology of

Indexed as

Biological SciencesDuchenne Muscular Dystrophygenetic modifierJagged-1mouse modelmusclesphysiology

Identifiers

PMID40161820
PMCPMC11952387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.