Evidence map›Paper›PMID 40161795›Full record

ArticlebioRxiv : the preprint server for biology2025

SORDINO for Silent, Sensitive, Specific, and Artifact-Resisting fMRI in awake behaving mice.

Martin J MacKinnon, Sheng Song, Tzu-Hao Harry Chao, Li-Ming Hsu, Scott T Albert, Yuncong Ma, Tatiana A Shnitko, Tzu-Wen Winnie Wang, Randy J Nonneman, Corey D Freeman and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Martin J MacKinnonCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sheng SongCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tzu-Hao Harry ChaoCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Li-Ming HsuCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Scott T AlbertNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yuncong MaCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tatiana A ShnitkoCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tzu-Wen Winnie WangCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Randy J NonnemanCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Corey D FreemanNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Siddhi S OzarkarNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Uzay E EmirDepartment of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Mark D ShenNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Benjamin D PhilpotNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Adam W HantmanNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sung-Ho LeeCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wei-Tang ChangBiomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yen-Yu Ian ShihCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Clyde W Hodge · 2003 to 2026
$46.3M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Postdoctoral Research in Neurodevelopmental DisordersT32HD040127 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN D PHILPOT, Mark D Shen · 2001 to 2026
$8.5M
UNC-CH NADIA Underage Drinking and Adult Brain Morphology in RatsU01AA020023 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CREWS, FULTON T · 2010 to 2024
$7.5M
MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISMP50AA011605 · NIAAA · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI SAMULSKI, RICHARD J · 1998 to 2002
$4.9M
Circuit Mechanisms Governing the Default Mode NetworkR01MH126518 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Vinod Menon, Yen-Yu Ian Shih · 2021 to 2026
$4.3M
Mechanisms underlying positive and negative BOLD in the striatumRF1MH117053 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2018 to 2019
$4.0M
Chemogenetic Dissection of Neuronal and Astrocytic Compartment of the BOLD SignalR01MH111429 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2016 to 2020
$2.7M
SORDINO-fMRI for mouse brain applicationsR01EB033790 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Yen-Yu Ian Shih · 2023 to 2026
$2.5M
Functional dissection of therapeutic deep brain stimulation circuitryR01NS091236 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2015 to 2019
$2.0M
9.4T Small Animal MRI scanner at UNCS10OD026796 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2020 to 2020
$2.0M
AVANCE NEO upgrade for the BioSpec 9.4T/30cm MRI system at UNCS10MH124745 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2020 to 2020
$600k
NIAAA NIH HHS P50 AA011605NIAAA NIH HHS P60 AA011605NIAAA NIH HHS U01 AA020023NIBIB NIH HHS R01 EB033790NICHD NIH HHS P50 HD103573NICHD NIH HHS T32 HD040127NIDA NIH HHS R21 DA057503NIH HHS S10 OD026796NIMH NIH HHS R01 MH111429NIMH NIH HHS R01 MH126518NIMH NIH HHS RF1 MH117053NIMH NIH HHS S10 MH124745NINDS NIH HHS R01 NS091236NINDS NIH HHS R21 NS133913
6 · The paper itself

Abstract

Blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has revolutionized our understanding of the brain activity landscape, bridging circuit neuroscience in animal models with noninvasive brain mapping in humans. This immensely utilized technique, however, faces challenges such as acoustic noise, electromagnetic interference, motion artifacts, magnetic-field inhomogeneity, and limitations in sensitivity and specificity. Here, we introduce

Indexed as

acoustic noiseawakebehaviorbrain networkscerebral blood volumeelectromagnetic interferencefMRIfunctional connectivitymotion artifactsmouseratsensitivitysocialspecificitysusceptibility artifactsT1 contrasttissue oxygen

Identifiers

PMID40161795
PMCPMC11952411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.