Evidence map›Paper›PMID 40161793›Full record

ArticlebioRxiv : the preprint server for biology2025

Calcium signals shape metabolic control of H3K27ac and H3K18la to regulate EGA.

Virginia Savy, Paula Stein, Don Delker, Martín A Estermann, Brian N Papas, Zongli Xu, Lenka Radonova, Carmen J Williams

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Virginia SavyReproductive Medicine Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0002-4942-1338
Paula SteinReproductive Medicine Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0002-2040-4593
Don DelkerIntegrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Martín A EstermannReproductive Developmental Biology Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0002-8623-2720
Brian N PapasIntegrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0003-4540-1142
Zongli XuBiostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0002-9034-8902
Lenka RadonovaReproductive Medicine Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0001-5965-8710
Carmen J WilliamsReproductive Medicine Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0001-6440-7086

Funding

Animal Research SupportZIGES102585 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI COBLE, DONDRAE · 2009 to 2025
$98.6M
Molecular Genetics Support to Identify Gene/Environment Interactions in DiseaseZICES102546 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GERRISH, KEVIN · 2009 to 2025
$30.5M
Epigenomics and DNA SequencingZICES102545 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WADE, PAUL A · 2012 to 2025
$27.4M
Protein Expression FacilityZICES102487 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PETROVICH, ROBERT · 2009 to 2025
$23.9M
Environmental influence on reproductive tract functionZIAES102405 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WILLIAMS, CARMEN · 2009 to 2025
$20.6M
NIEHS Knock Out Mouse Core (KOMC) Annual ReportZICES102425 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RAY, MANAS · 2010 to 2025
$20.1M
Fluorescence MicroscopyZICES102485 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SCAPPINI, ERICA · 2012 to 2025
$16.6M
Integrative BioinformaticsZICES103371 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LI, JIAN-LIANG · 2022 to 2025
$11.5M
Calcium-mediated mechanisms of metabolic and epigenetic changes at fertilizationR00HD112510 · NICHD · EAST CAROLINA UNIVERSITY · PI Virginia Savy · 2026 to 2026
$249k
Intramural NIH HHS ZIA ES102405Intramural NIH HHS ZIC ES102425Intramural NIH HHS ZIC ES102485Intramural NIH HHS ZIC ES102487Intramural NIH HHS ZIC ES102545Intramural NIH HHS ZIC ES102546Intramural NIH HHS ZIC ES103371Intramural NIH HHS ZIG ES102585NICHD NIH HHS R00 HD112510
6 · The paper itself

Abstract

The use of assisted reproductive technologies (ART) has enabled the birth of over 9 million babies; but it is associated with increased risks of negative metabolic outcomes in offspring. Yet, the underlying mechanism remains unknown. Calcium (Ca

Indexed as

artificial oocyte activation (AOA)DOHaDlactylationMetabolofertilityzygotic genome activation (ZGA)

Identifiers

PMID40161793
PMCPMC11952514

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.