ArticlebioRxiv : the preprint server for biology2025
Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition.
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Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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67 authors.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Wei ZhaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Christopher WirthManchester Cancer Research Centre, The University of Manchester, Manchester, UK.
Marcos Díaz-GayDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Jinhu YinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Monia CecatiAdvanced Technology Center for Aging Research, IRCCS INRCA, Ancona, Italy.
Francesca MarchegianiClinic of Laboratory and Precision Medicine, IRCCS INRCA, Ancona, Italy.
Phuc H HoangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Charles LeducDepartment of Pathology, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
Marina K BaineDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
William D TravisDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lynette M ShollDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Philippe JoubertInstitut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec City, Canada.
Jian SangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
John P McElderryDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Alyssa KleinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Azhar KhandekarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Caleb HartmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jennifer RosenbaumWestat, Rockville, MD, USA.
Frank J Colón-MatosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Mona MiraftabDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Monjoy SahaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Olivia W LeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Kristine M JonesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Maria Pik WongQueen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Kin Chung LeungDepartment of Pathology, The University of Hong Kong, Hong Kong, China.
Chao Agnes HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Chih-Yi ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Eric S EdellDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Jacobo Martínez SantamaríaBiobanco IBSP-CV FISABIO, Valencia, Spain.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Sai S YendamuriThoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Marta ManczukDepartment of Cancer Epidemiology and Primary Prevention, Maria Skłodowska-Curie National Research Institute of Oncology, Warshaw, Poland.
Jolanta LissowskaDepartment of Cancer Epidemiology and Primary Prevention, Maria Skłodowska-Curie National Research Institute of Oncology, Warshaw, Poland.
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.
Anush MukeriaDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Oxana ShanginaDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
David ZaridzeDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Ivana HolcatovaInstitute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Dana MatesDepartment of Occupational Health and Toxicology, National Center for Environmental Risk Monitoring, National Institute of Public Health, Bucharest, Romania.
Sasa MilosavljevicInternational Organisation for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.
Milan SavicDepartment of Thoracic Surgery, Clinical Center of Serbia, Belgrade, Serbia.
Yohan BosséInstitut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec City, Canada.
Bonnie E Gould RothbergSylvester Comprehensive Cancer Center, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Valerie GaborieauGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Geoffrey LiuPrincess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada.
Paul HofmanIHU RespirERA, Biobank-BB-0033-0025, Côte d'Azur University, Nice, France.
Robert HomerDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Soo-Ryum YangDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Angela C PesatoriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Dario ConsonniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Lixing YangBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Kevin BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Jiyeon ChoiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Maurizio CardelliAdvanced Technology Center for Aging Research, IRCCS INRCA, Ancona, Italy.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Martin A NowakDepartment of Mathematics, Harvard University, Cambridge, MA, USA.
David C WedgeManchester Cancer Research Centre, The University of Manchester, Manchester, UK.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Funding
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MDetecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4MMapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1MComprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2MNCI NIH HHS R01 CA269919NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA290479NIEHS NIH HHS R01 ES032547
Abstract
Understanding lung cancer evolution can identify tools for intercepting its growth. In a landscape analysis of 1024 lung adenocarcinomas (LUAD) with deep whole-genome sequencing integrated with multiomic data, we identified 542 LUAD that displayed diverse clonal architecture. In this group, we observed an interplay between mobile elements, endogenous and exogenous mutational processes, distinct driver genes, and epidemiological features. Our results revealed divergent evolutionary trajectories based on tobacco smoking exposure, ancestry, and sex. LUAD from smokers showed an abundance of tobacco-related C:G>A:T driver mutations in
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.