Evidence map›Paper›PMID 40161725›Full record

ArticlebioRxiv : the preprint server for biology2025

Progressively reduced cerebral oxygen metabolism and elevated plasma NfL levels in the zQ175DN mouse model of Huntington's disease.

Qian Wu, Minmin Yao, Hongshuai Liu, Aaron Kakazu, Yuxiao Ouyang, Chang Liu, Ruoxuan Li, Fan Yang, Anqi Wang, Sharmane Surasinghe and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Qian Wu
Minmin Yao
Hongshuai Liu
Aaron Kakazu
Yuxiao Ouyang
Chang Liu
Ruoxuan Li
Fan Yang
Anqi Wang
Sharmane Surasinghe
Damien Gerochi
Barbara Baldo
Stefanie Jahn
Haiying Tang
Hanzhang Lu
Zhiliang Wei
Wenzhen Duan

Funding

Advanced MRI biomarkers in HD mouse models translatable to humans: nature history and response to therapeuticsR01NS124084 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DUAN, WENZHEN · 2022 to 2025
$2.6M
Developing HTS assays for identifying NLK activators to target Huntington's diseaseR21NS135139 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DUAN, WENZHEN · 2023 to 2023
$450k
NINDS NIH HHS R01 NS124084NINDS NIH HHS R21 NS135139
6 · The paper itself

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG-repeat expansion in exon-1 of the

Identifiers

PMID40161725
PMCPMC11952543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.