Evidence map›Paper›PMID 40161724›Full record

ArticlebioRxiv : the preprint server for biology2025

Sequencing-free whole genome spatial transcriptomics at molecular resolution in intact tissue.

Yubao Cheng, Shengyuan Dang, Yuan Zhang, Yanbo Chen, Ruihuan Yu, Miao Liu, Shengyan Jin, Ailin Han, Samuel Katz, Siyuan Wang

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Yubao ChengDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Shengyuan DangDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Yuan ZhangDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Yanbo ChenDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Ruihuan YuDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Miao LiuDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Shengyan JinDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Ailin HanDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Samuel KatzDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
Siyuan WangDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.

Funding

Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung CancerP50CA196530 · NCI · YALE UNIVERSITY · PI Roy S Herbst · 2015 to 2026
$31.1M
Genome Architecture in Human Germinal Center B Cell Development, Malignancy, and Somatic HypermutationU01CA260701 · NCI · YALE UNIVERSITY · PI SCHATZ, DAVID G., WANG, SIYUAN · 2020 to 2024
$3.1M
Building the 3D genomic regulatomeDP2GM137414 · NIGMS · YALE UNIVERSITY · PI WANG, SIYUAN · 2019 to 2019
$2.5M
Spatial omics technologies to map the senescent cell microenvironmentUH3CA268202 · NCI · BROWN UNIVERSITY · PI MA, JIAN, NERETTI, NICOLA · 2023 to 2025
$2.2M
Multimodal Analysis of the Genome Architecture Using Expansion MicroscopyR01HG012969 · NHGRI · YALE UNIVERSITY · PI Joerg Bewersdorf, Antonio J Giraldez · 2024 to 2026
$2.1M
Integrative single-cell spatial genomic, transcriptomic, and epigenetic imaging in mammalian tissueR01HG011245 · NHGRI · YALE UNIVERSITY · PI WANG, SIYUAN · 2020 to 2023
$2.1M
3D genome reorganization drives cancer developmentR01CA292936 · NCI · YALE UNIVERSITY · PI Mandar Deepak Muzumdar, Siyuan Wang · 2024 to 2026
$2.1M
Developing next-generation high-content image-based genetic screens for multi-omic spatial phenotypesR01HG013503 · NHGRI · YALE UNIVERSITY · PI Siyuan Wang · 2024 to 2026
$2.0M
Enhancing Melanoma TIL Efficacy with Multifactor mRNA-Mediated T Cell ReprogrammingR21CA282629 · NCI · YALE UNIVERSITY · PI HURWITZ, MICHAEL E, KATZ, SAMUEL G · 2023 to 2024
$539k
NCI NIH HHS P50 CA196530NCI NIH HHS R01 CA292936NCI NIH HHS R21 CA282629NCI NIH HHS U01 CA260701NCI NIH HHS UH3 CA268202NHGRI NIH HHS R01 HG011245NHGRI NIH HHS R01 HG012969NHGRI NIH HHS R01 HG013503NIGMS NIH HHS DP2 GM137414
6 · The paper itself

Abstract

Recent breakthroughs in spatial transcriptomics technologies have enhanced our understanding of diverse cellular identities, compositions, interactions, spatial organizations, and functions. Yet existing spatial transcriptomics tools are still limited in either transcriptomic coverage or spatial resolution. Leading spatial-capture or spatial-tagging transcriptomics techniques that rely on

Identifiers

PMID40161724
PMCPMC11952344

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.