Evidence map›Paper›PMID 40161721›Full record

ArticlebioRxiv : the preprint server for biology2025

Independent mechanisms of benzimidazole resistance across

Amanda O Shaver, Ryan McKeown, Joyce M Reyes Otero, Erik C Andersen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Amanda O ShaverDept. of Biology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-2910-1505
Ryan McKeownDept. of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0003-3570-2494
Joyce M Reyes OteroDept. of Biology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0009-0002-5039-4434
Erik C AndersenDept. of Biology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-0229-9651

Funding

Developing Capacity to Evaluate Training Programs via Development of Human, Institutional and Social CapitalT32GM008449 · NIGMS · NORTHWESTERN UNIVERSITY · PI LEONARD, JOSHUA NATHANIEL · 1993 to 2023
$7.8M
Discovery of Novel Benzimidazole Resistance MechanismsR01AI153088 · NIAID · NORTHWESTERN UNIVERSITY · PI Erik Christian Andersen, James Solomon Fraser · 2020 to 2026
$4.3M
Discovery of the mechanisms of resistance for the anthelmintic emodepsideF32AI181342 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Amanda Shaver · 2024 to 2026
$234k
NIAID NIH HHS F32 AI181342NIAID NIH HHS R01 AI153088NIGMS NIH HHS T32 GM008449
6 · The paper itself

Abstract

Benzimidazoles (BZs), a widely used class of anthelmintic drugs, target beta-tubulin proteins, disrupt microtubule formation, and cause nematode death. In parasitic nematode species, mutations in beta-tubulin genes (

Indexed as

benzimidazolesbeta-tubulinC. briggsaeC. elegansC. tropicalisRepeated evolution

Identifiers

PMID40161721
PMCPMC11952494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.