Evidence map›Paper›PMID 40161720›Full record

ArticlebioRxiv : the preprint server for biology2025

Uridine-sensitized screening identifies genes and metabolic regulators of nucleotide synthesis.

Abigail Strefeler, Zakery N Baker, Sylvain Chollet, Rachel M Guerra, Julijana Ivanisevic, Hector Gallart-Ayala, David J Pagliarini, Alexis A Jourdain

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Abigail StrefelerDepartment of Immunobiology, University of Lausanne, Epalinges, Switzerland.ORCID 0000-0003-0149-4981
Zakery N BakerDepartment of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, USA.ORCID 0000-0002-0503-9460
Sylvain CholletDepartment of Immunobiology, University of Lausanne, Epalinges, Switzerland.ORCID 0009-0008-7769-844X
Rachel M GuerraDepartment of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, USA.
Julijana IvanisevicMetabolomics Platform, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-8267-2705
Hector Gallart-AyalaMetabolomics Platform, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-2333-0646
David J PagliariniDepartment of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, USA.ORCID 0000-0002-0001-0087
Alexis A JourdainDepartment of Immunobiology, University of Lausanne, Epalinges, Switzerland.ORCID 0000-0001-5321-6938

Funding

Systems-to-structure approaches for defining mitochondrial protein functionR35GM131795 · NIGMS · WASHINGTON UNIVERSITY · PI David J Pagliarini · 2019 to 2026
$4.8M
NIGMS NIH HHS R35 GM131795
6 · The paper itself

Abstract

Nucleotides are essential for nucleic acid synthesis, signaling, and metabolism, and can be synthesized

Indexed as

amidophosphoribosyltransferaseCOQ7CRISPR screendemethoxy-coenzyme Qnucleotide imbalanceNUDIX5purinepyrimidineuridine

Identifiers

PMID40161720
PMCPMC11952425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.