Evidence map›Paper›PMID 40161715›Full record

ArticlebioRxiv : the preprint server for biology2025

Transcriptomic Analysis of CAD Cell Differentiation.

Carlos A Cevallos, Anna Leigh White, Brooke A Fazio, Lillian S Wendt, Jasmine W Feng, Dora Posfai, April L Horton, John M Warrick, Omar A Quintero-Carmona

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Carlos A CevallosDepartment of Biology, University of Richmond, VA, 23173.
Anna Leigh WhiteDepartment of Biology, University of Richmond, VA, 23173.ORCID 0009-0004-9081-1268
Brooke A FazioDepartment of Biology, University of Richmond, VA, 23173.
Lillian S WendtDepartment of Biology, University of Richmond, VA, 23173.ORCID 0009-0005-3939-1832
Jasmine W FengDepartment of Biology, University of Richmond, VA, 23173.ORCID 0009-0009-1778-7915
Dora PosfaiDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, 27708.ORCID 0000-0003-3965-6456
April L HortonDepartment of Biology, University of Richmond, VA, 23173.ORCID 0000-0001-6810-7435
John M WarrickDepartment of Biology, University of Richmond, VA, 23173.
Omar A Quintero-CarmonaDepartment of Biology, University of Richmond, VA, 23173.ORCID 0000-0002-9314-1704

Funding

Myosin-XIX and the molecular mechanism of actin-based mitochondrial organizationR15GM119077 · NIGMS · UNIVERSITY OF RICHMOND · PI QUINTERO-CARMONA, OMAR ALBERTO · 2016 to 2017
$548k
NIGMS NIH HHS R15 GM119077
6 · The paper itself

Abstract

CAD cells were derived from Cath.a cells, a mouse central nervous system catecholaminergic cell line. Serum-starved CAD cells undergo morphological changes and resemble isolated neurons when observed by microscopy. We carried out an RNAseq transcriptomic analysis to examine differentiated CAD cells for expression signatures related to neuronal functions, identifying ~1900 transcripts whose expression changed with differentiation. Pathview analysis identified ~80 KEGG pathway gene sets that were differentially expressed, including upregulation of at least 13 neuron-related pathways. This dataset can be explored more deeply, allowing further investigation into expression changes relevant to studying neuronal functions in this easy-to-culture model system.

Identifiers

PMID40161715
PMCPMC11952321

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.