Evidence map›Paper›PMID 40161708›Full record

ArticlebioRxiv : the preprint server for biology2025

Targeting Galectin-3 to modulate inflammation in LAMA2-deficient congenital muscular dystrophy.

Yonne Karoline Tenorio de Menezes, Jinseo Lee, Jia Qi Cheng-Zhang, Marie A Johnson, Ruvindi N Ranatunga, Dwi U Kemaladewi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yonne Karoline Tenorio de MenezesDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Jinseo LeeDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Jia Qi Cheng-ZhangDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Marie A JohnsonDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Ruvindi N RanatungaDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Dwi U KemaladewiDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, USA.

Funding

Implications of Genetic Diversity in Muscular DystrophyDP2AR081047 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KEMALADEWI, DWI UTAMI · 2021 to 2024
$2.2M
Therapeutic genetics and disease modeling in LAMA2-CMDR01AR078872 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GERARD VOCKLEY · 2022 to 2026
$2.2M
NIAMS NIH HHS DP2 AR081047NIAMS NIH HHS R01 AR078872
6 · The paper itself

Abstract

LAMA2-deficient congenital muscular dystrophy (LAMA2-CMD) is a severe neuromuscular disorder characterized by muscle degeneration, chronic inflammation, and fibrosis. While inflammation is one the hallmarks of LAMA2-CMD, the immune cell composition in laminin-deficient muscles remains understudied. Consequently, targeted pharmacological intervention to reduce inflammation remains underexplored. Here, we characterized the immune landscape in the dyW mouse model of LAMA2-CMD using RNA sequencing and flow cytometry. Transcriptomic analysis of dyW quadriceps femoris muscle identified 2,143 differentially expressed genes, with most upregulated genes linked to immune-related pathways.

Identifiers

PMID40161708
PMCPMC11952532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.