Evidence map›Paper›PMID 40161706›Full record

ArticlebioRxiv : the preprint server for biology2025

Magnetically Labeled iPSC-Derived Extracellular Vesicles Enable MRI/MPI-Guided Regenerative Therapy for Myocardial Infarction.

Wenshen Wang, Zheng Han, Safiya Aafreen, Cristina Zivko, Olesia Gololobova, Zhiliang Wei, Geoffrey Cotin, Delphine Felder-Flesc, Vasiliki Mahairaki, Kenneth W Witwer and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Wenshen WangF.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, USA.
Zheng HanF.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, USA.
Safiya AafreenF.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, USA.
Cristina ZivkoDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Olesia GololobovaDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zhiliang WeiF.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, USA.
Geoffrey CotinSUPERBRANCHE SAS, Strasbourg, France.
Delphine Felder-FlescSUPERBRANCHE SAS, Strasbourg, France.
Vasiliki MahairakiDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6281-5895
Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1664-4233
Jeff W M BulteF.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, USA.ORCID 0000-0003-1202-1610
Robert G WeissRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4451-8373
Guanshu LiuF.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, USA.ORCID 0000-0002-8188-4332

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Multimodal MRI for guiding bacterial cancer therapyR01CA261974 · NCI · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Renyuan Bai, Guanshu Liu · 2022 to 2026
$1.8M
MPI/MRI bimodal imaging for non-invasive tracking of extracellular vesicles targeted to infarcted myocardiumR33HL161756 · NHLBI · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LIU, GUANSHU · 2022 to 2023
$966k
Magnetic Particle Imaging ScannerS10OD026740 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BULTE, JEFF W. · 2019 to 2019
$600k
NCI NIH HHS R01 CA261974NHLBI NIH HHS R33 HL161756NIBIB NIH HHS P41 EB024495NIH HHS S10 OD026740
6 · The paper itself

Abstract

Stem cell-derived extracellular vesicles (EVs) offer a promising cell-free approach for cardiovascular regenerative medicine. In this study, we developed magnetically labeled induced pluripotent stem cell-derived EVs (magneto-iPSC-EVs) encapsulated with superparamagnetic iron oxide (SPIO) nanoparticles for image-guided regenerative treatment of myocardial infarction, in which EVs that can be detected by both magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). iPSC-EVs were isolated, characterized per MISEV2023 guidelines, and loaded with SuperSPIO20 nanoparticles using optimized electroporation conditions (300 V, 2 × 10 ms pulses), achieving a high loading efficiency of 1.77 ng Fe/10

Indexed as

Extracellular vesiclesiPSC-EVsMPIMRImyocardial infarctionSPIOtheranostics

Identifiers

PMID40161706
PMCPMC11952340

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.